Studies (n = 13) evaluating liver stiffness by VCTE and HCC occurrence in patients with HCV
| Author & year | Region | SVR | Patients (n) | Mean age (years) | F-U months | HCC (n) | Prevalence (%) | Proposed cut-off (kPa) | AUROC | Sens (%) | Spec (%) | PPV | NPV | LR+ | LR– |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Masuzaki et al., 2008 [29] | Japan | - | 265 | - | 8 | 85 | 32 | ≥ 25 | 0.805 | - | - | - | - | - | - |
| Masuzaki et al., 2009 [30] | Japan | No | 866 | 62.2 ± 11.3 | 36 | 77 | 8.9 | ≥ 25 | - | - | - | - | - | - | - |
| Wang et al., 2013 [27] | Taiwan, China | Mixed | 198 | 53.0 ± 11.2 | 47.8 | 10 | 5 | ≥ 12 | - | - | - | - | - | - | - |
| Calvaruso et al., 2013 [31] | Italy | No | 233 | - | 42 ± 18 | 20 | 8.5 | ≥ 21 | 0.73 | 70 | 60 | - | - | 1.75 | 0.5 |
| Feier et al., 2013 [32] | Romania | No | 184 | 62.23 | - | 72 | 39 | ≥ 38.5 | 0.68 | 51.7 | 90.4 | 86.1 | 61.8 | 5.2 | 0.5 |
| Narita et al.,2014 [33] | Japan | No | 151 | 62 | 24 | 9 | 5.9 | ≥ 14 | - | - | - | - | - | - | - |
| Wang et al., 2016 [34] | Taiwan, China | SVR | 278 | 54.1 | 91.2 | 18 | 6.5 | ≥ 12 | 0.781 | 55.6 | 91.9 | - | - | 0.7 | 0.5 |
| D’Ambrosio et al., 2018 [35] | Italy | No | 404 | 63 | 36 | 24 | 6 | ≥ 30 | - | - | - | - | - | - | - |
| Degasperi et al, 2019 [36] | Italy | No | 546 | 64 | 25 | 28 | 5 | ≥ 30 | - | - | - | - | - | - | - |
| Nakagomi et al., 2019 [28] | Japan | No | 1,146 | 63 | 79.2 | 190 | 16.5 | - | - | - | - | - | - | - | - |
| Pons et al., 2020 [37] | Spain | SVR | 572 | 63.7 | 33.6 | 25 | 4 | - | - | - | - | - | - | - | - |
| Izumi et al, 2019 [21] | Japan | Mixed | 419 | - | 30 | 32 | 7.6 | ≥ 8 | 0.80592 | 84.4 | 63.3 | 16.1 | 98 | 2.3 | 0.25 |
| Rinaldi et al., 2019 [38] | Italy | SVR | 258 | 68 | 24 | 35 | 13.5 | ≥ 27.8 | 0.691 | 72 | 65 | - | - | 2.05 | 0.4 |
SVR: sustained virological response; VCTE: vibration-controlled transient elastography