Studies (n = 3) evaluating liver stiffness by VCTE and HCC occurrence in patients with NAFLD
| Author & year | Region | Patients (n) | Mean age (years) | F-U months | HCC (n) | Prevalence (%) | Proposed cut-off (kPa) | AUROC | Sens (%) | Spec (%) | PPV | NPV | LR+ | LR– |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Izumi et al., 2019 [21] | Japan | 258 | - | 30 | 33 | 13 | ≥ 5.4 | 0.69 | 93.9 | 35.1 | 17.5 | 97.5 | 1.43 | 2 |
| Shili-Masmoudi et al., 2020 [62] | France/Asia/Australia | 2,251 | 59.4 | 27 | - | - | ≥ 12 | - | - | - | - | - | - | - |
| Lee et al., 2021 [63] | Korea | 2,666 | 52 | 64.6 | 22 | 0.8 | ≥ 9.3 | - | - | - | - | - | - | - |
NAFLD: non-alcoholic fatty liver disease; VCTE: vibration-controlled transient elastography