Plasma membrane transporters and channels involved in hepatobiliary function
| Cells | Membrane | Protein | Gene | Substrates |
|---|---|---|---|---|
| Hepatocytes | Basolateral | NTCP | SLC10A1 | Bile acids |
| OATP1B1 | SLCO1B1 | Bile acids, organic anions | ||
| OATP1B3 | SLCO1B3 | Bile acids, organic anions | ||
| MRP3 | ABCC3 | Bile acids, organic anions | ||
| MRP4 | ABCC4 | Bile acids, organic anions | ||
| NBC4 | SLC4A5 | Na+/HCO3–symporter | ||
| NHE1 | SLC9A1 | Na+/H+ antiporter | ||
| SK2 | KCNN2 | K+ channel | ||
| BSC | SLC12A2 | Na+/Cl– symporter | ||
| AQP9 | AQP9 | Water channel | ||
| Hepatocytes | Canalicular | BSEP | ABCB11 | Bile acids |
| MRP2 | ABCC2 | Organic anions | ||
| MDR1 | ABCB1 | Several | ||
| BCRP | ABCG2 | Bile acids, steroids | ||
| MDR3 | ABCB4 | Phosphatidyl choline | ||
| FIC1 | ATP8B1 | Phosphatidyl serine | ||
| ABCG5/G8 | ABCG5/G8 | Cholesterol | ||
| NHE3 | SLC9A3 | Na+/H+ antiporter | ||
| AQP8 | AQP8 | Water channel | ||
| Cholangiocytes | Basolateral | OSTα/β | SLC51A/B | Bile acids, organic anions |
| NHE1 | SLC9A1 | Na+/H+ antiporter | ||
| NDCBE | SLC4A8 | Cl–/HCO3– antiporter | ||
| SK2 | KCNN2 | K+ channel | ||
| BSC | SLC12A2 | Na+/Cl– symporter | ||
| MRP3 | ABCC3 | Bile acids, organic anions | ||
| MRP4 | ABCC4 | Bile acids, organic anions | ||
| AQP4 | AQP4 | Water channel | ||
| Cholangiocytes | Apical | ASBT | SLC10A2 | Bile acids |
| AE2 | SLC4A2 | Cl–/HCO3– antiporter | ||
| CFTR | ABCC7 | Cl– channel | ||
| NBC4 | SLC4A5 | Na+/HCO3– symporter | ||
| AQP1 | AQP1 | Water channel |
BCRP: breast cancer resistance protein; HCO3–: bicarbonate; KCNN2: potassium calcium-activated channel subfamily N member 2