Exploration of Musculoskeletal Diseases

Gene	Chr	Protein function in HH pathway	Disease (manifestation)	References
GNAS	20	Encodes Gα_s which inhibits HH signaling pathway through cAMP and PKA	POH (OMIM#166350)	[148]
PTCH1	9	Transmembrane protein that functions as a receptor for the secreted HH signaling molecules	Gorlin syndrome (OMIM#109400)	[151]

Declarations

Author contributions

BP: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. ARC and LP: Writing—review & editing. JBA: Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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