Exploration of Musculoskeletal Diseases

Open Access

Editorial

Opening editorial for exploration in musculoskeletal diseases

Fernando Perez-Ruiz

Published: January 01, 2023 Explor Musculoskeletal Dis. 2023;1:1–3
DOI: https://doi.org/10.37349/emd.2022.00001

Full Text

PDF

Download:51

Times Cited: 0

Open Access

Review

Perioperative management, operative techniques, and pitfalls in the surgical treatment of patients with diffuse idiopathic skeletal hyperostosis: a narrative review

Diffuse idiopathic skeletal hyperostosis (DISH) can lead to dysphagia, airway obstruction, and unstable vertebral fractures. Surgery can be performed to relieve cervical compression or stabilize fra [...] Read more.

Netanja I. Harlianto ... Jorrit-Jan Verlaan

Published: August 29, 2023 Explor Musculoskeletal Dis. 2023;1:84–96
DOI: https://doi.org/10.37349/emd.2023.00013
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:24

Times Cited: 1

Open Access

Original Article

Real-life results of urate-driven pharmacotherapy with three urate lowering drugs in gout: allopurinol, febuxostat and benzbromarone

Aim: This study aims to assess outcomes of gout patients from the treat to target (T2T) perspective at 6 months and 12 months while using urate lowering therapy (ULT): allopurinol, febuxostat, an [...] Read more.

Ioana Hotea ... Tim L. Jansen

Published: August 30, 2023 Explor Musculoskeletal Dis. 2023;1:97–105
DOI: https://doi.org/10.37349/emd.2023.00014

Full Text

PDF

Download:18

Times Cited: 1

Open Access

Review

Premature mortality with gout and hyperuricemia may be reduced by early resolution of comorbid obstructive sleep apnea

Hyperuricemia is known to be a necessary and causal condition for gout, but much more prevalent than gout. Medicine has standardized treatments for gout, but has no such determination for asymptomat [...] Read more.

Burton Abrams

Published: August 31, 2023 Explor Musculoskeletal Dis. 2023;1:106–120
DOI: https://doi.org/10.37349/emd.2023.00015
This article belongs to the special issue Hyperuricemia current state and prospects

Full Text

PDF

Download:41

Times Cited: 1

Open Access

Original Article

Prevalence and factors associated to diffuse idiopathic skeletal hyperostosis in gout

Aim: To evaluate the prevalence, associated factors, and the impact of diffuse idiopathic skeletal hyperostosis (DISH) in patients with gout. Methods: Patients with gout entering into an in [...] Read more.

Fernando Pérez-Ruiz ... Ana María Herrero-Beites

Published: September 27, 2023 Explor Musculoskeletal Dis. 2023;1:121–127
DOI: https://doi.org/10.37349/emd.2023.00016
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:25

Times Cited: 1

Open Access

Review

Interstitial lung disease in patients with rheumatoid arthritis: a narrative review

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease of unknown origin. Although it mainly affects joints, it can have extra-articular manifestations, with the lung being one [...] Read more.

Gloria Candelas Rodríguez, Virginia Villaverde

Published: October 20, 2023 Explor Musculoskeletal Dis. 2023;1:128–142
DOI: https://doi.org/10.37349/emd.2023.00017
This article belongs to the special issue Comorbidities in rheumatoid arthritis

Full Text

PDF

Download:85

Times Cited: 0

Open Access

Review

Genetic basis for skeletal new bone formation

Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, includi [...] Read more.

Bruna Parreira ... Jácome Bruges-Armas

Published: October 23, 2023 Explor Musculoskeletal Dis. 2023;1:143–170
DOI: https://doi.org/10.37349/emd.2023.00018
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:56

Times Cited: 0

Open Access

Original Article

Lessons to be learned from real life data based on 98 gout patients using benzbromarone

Aim: This study aims to analyze the efficacy and safety of benzbromarone as uricosuric, in a real-life clinical setting of a retrospective hospital-based gout cohort. Methods: Data from gou [...] Read more.

Ioana Hotea ... Tim L. Jansen

Published: October 30, 2023 Explor Musculoskeletal Dis. 2023;1:171–179
DOI: https://doi.org/10.37349/emd.2023.00019

Full Text

PDF

Download:18

Times Cited: 0

Open Access

Perspective

Nutritional problems in rheumatoid arthritis patients with temporomandibular joint involvement

Rheumatoid arthritis (RA) is an inflammatory arthritis that affects synovial joints, and it is not surprising that the temporomandibular joint (TMJ), a synovial joint, is also affected. However, TMJ [...] Read more.

Manolya Ilhanli, Ilker Ilhanli

Published: October 31, 2023 Explor Musculoskeletal Dis. 2023;1:180–185
DOI: https://doi.org/10.37349/emd.2023.00020
This article belongs to the special issue Comorbidities in rheumatoid arthritis

Full Text

PDF

Download:21

Times Cited: 0

Open Access

Original Article

Association of mutations in hemochromatosis genes with clinical severity of calcium pyrophosphate arthritis

Aims: To study factors associated with the development of calcium pyrophosphate (CPP) arthritis and the severity phenotype. Methods: Transversal case-control study. Cases had to be confirme [...] Read more.

Joana Atxotegi-Saenz de Buruaga ... Fernando Perez-Ruiz

Published: October 31, 2023 Explor Musculoskeletal Dis. 2023;1:186–193
DOI: https://doi.org/10.37349/emd.2023.00021

Full Text

PDF

Download:23

Times Cited: 1

Open Access

Editorial

Quality of care, referral, and early diagnosis of axial spondyloarthritis

Jürgen Braun ... Xenofon Baraliakos

Published: April 12, 2023 Explor Musculoskeletal Dis. 2023;1:37–42
DOI: https://doi.org/10.37349/emd.2023.00007

Full Text

PDF

Download:53

Times Cited: 0

Open Access

Review

Is there a place for magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis?

Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by the new bone formation and enthesopathies of the axial and peripheral skeleton. The diagnosis of DISH current [...] Read more.

Iris Eshed

Published: April 27, 2023 Explor Musculoskeletal Dis. 2023;1:43–53
DOI: https://doi.org/10.37349/emd.2023.00008
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:51

Times Cited: 1

Open Access

Original Article

Quantitative magnetic resonance spectroscopy and imaging analysis of the lipid content in the psoas major and its association with intervertebral disc degeneration: a cross-sectional study

Aim: It is shown that the diminished function of the psoas major is mainly associated with increased lipid content; nonetheless, whether the fat content of the psoas major is associated with inte [...] Read more.

Izaya Ogon ... Atsushi Teramoto

Published: June 29, 2023 Explor Musculoskeletal Dis. 2023;1:54–63
DOI: https://doi.org/10.37349/emd.2023.00009

Full Text

PDF

Download:12

Times Cited: 0

Open Access

Letter to the Editor

Patient self-sampling for remote human leucocyte antigen-B27 analysis

Hannah Labinsky ... Johannes Knitza

Published: June 30, 2023 Explor Musculoskeletal Dis. 2023;1:64–67
DOI: https://doi.org/10.37349/emd.2023.00010
This article belongs to the special issue Digital health technologies in rheumatology: emerging evidence and innovation

Full Text

PDF

Download:36

Times Cited: 0

Open Access

Original Article

Morphological variations at the knee associated with osteoarthritis: a case-control study using data from the GOAL study

Aim: To identify constitutional morphological features at the knee that associate with knee osteoarthritis (OA, KOA). Methods: This was a case-control study using data from the Genetics of [...] Read more.

Aim: To identify constitutional morphological features at the knee that associate with knee osteoarthritis (OA, KOA). Methods: This was a case-control study using data from the Genetics of Osteoarthritis and Lifestyle (GOAL) study. Radiographic measurements at the knee were undertaken by a single trained observer. Measurement of 12 characteristics was undertaken in 815 controls with asymptomatic structurally normal knees to examine right-left symmetry and variation with gender and age. Measurements were then compared to “cases” (315 asymptomatic and structurally unaffected knees of people with radiographic and symptomatic OA in the contralateral knee) on the assumption that the morphology of the unaffected knee represented the morphology of the contralateral knee prior to the development of OA. Right-left symmetry of morphological measures in controls was examined using paired t test and minimal detectable change (MDC). Linear regression was used to examine the association between measurements and demographic characteristics. Association of morphological features and unilateral KOA [defined as OA in either patellofemoral (PF) or tibiofemoral (TF) joints], PFOA and TFOA were determined using binary logistic regression and odds ratio (OR) and 95% confidence interval (CI) calculated. Cumulative risk of measurements in determining OA was examined using receiver operating characteristic (ROC) curves. Results: Narrow sulcus and condylar angles, increasing distal femoral, proximal tibial tilt, and increasing varus alignment associated with KOA. ROC curves including all significant morphological features and age, gender, height, and weight predicted knee, PF joint (PFJ), and TF joint (TFJ) OA with area under the curve (AUC) of 0.91, 0.89, and 0.90 respectively. On the contrary, a model only containing age, gender, height, and weight predicted knee, PFJ, and TFJ OA with AUC of 0.59, 0.67, and 0.59 respectively. Conclusions: Five morphological features associated independently with KOA were identified. Together they explain a large proportion of risk for OA.

Anand Ramachandran Nair ... Abhishek Abhishek

Published: June 30, 2023 Explor Musculoskeletal Dis. 2023;1:68–76
DOI: https://doi.org/10.37349/emd.2023.00011

Full Text

PDF

Download:25

Times Cited: 0

Aim: To identify constitutional morphological features at the knee that associate with knee osteoarthritis (OA, KOA). Methods: This was a case-control study using data from the Genetics of Osteoarthritis and Lifestyle (GOAL) study. Radiographic measurements at the knee were undertaken by a single trained observer. Measurement of 12 characteristics was undertaken in 815 controls with asymptomatic structurally normal knees to examine right-left symmetry and variation with gender and age. Measurements were then compared to “cases” (315 asymptomatic and structurally unaffected knees of people with radiographic and symptomatic OA in the contralateral knee) on the assumption that the morphology of the unaffected knee represented the morphology of the contralateral knee prior to the development of OA. Right-left symmetry of morphological measures in controls was examined using paired t test and minimal detectable change (MDC). Linear regression was used to examine the association between measurements and demographic characteristics. Association of morphological features and unilateral KOA [defined as OA in either patellofemoral (PF) or tibiofemoral (TF) joints], PFOA and TFOA were determined using binary logistic regression and odds ratio (OR) and 95% confidence interval (CI) calculated. Cumulative risk of measurements in determining OA was examined using receiver operating characteristic (ROC) curves. Results: Narrow sulcus and condylar angles, increasing distal femoral, proximal tibial tilt, and increasing varus alignment associated with KOA. ROC curves including all significant morphological features and age, gender, height, and weight predicted knee, PF joint (PFJ), and TF joint (TFJ) OA with area under the curve (AUC) of 0.91, 0.89, and 0.90 respectively. On the contrary, a model only containing age, gender, height, and weight predicted knee, PFJ, and TFJ OA with AUC of 0.59, 0.67, and 0.59 respectively. Conclusions: Five morphological features associated independently with KOA were identified. Together they explain a large proportion of risk for OA.

Open Access

Review

Significance of autoantibodies in diagnostics of systemic vasculitis

Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. Patients usually present a quite broad spectrum of manifestations which vary [...] Read more.

Katarzyna Fischer, Marek Brzosko

Published: July 17, 2023 Explor Musculoskeletal Dis. 2023;1:77–83
DOI: https://doi.org/10.37349/emd.2023.00012

Full Text

PDF

Download:30

Times Cited: 0

Open Access

Review

Diffuse idiopathic skeletal hyperostosis and axial spondyloarthritis—similarities and differences

Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axSpA) are diseases with inflammatory involvement of the axial skeleton that can result in new bone formation that may le [...] Read more.

Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axSpA) are diseases with inflammatory involvement of the axial skeleton that can result in new bone formation that may lead to total ankylosis of the spine and functional impairment of different extent in individual patients. In these diseases, the new bone formation may lead to total ankylosis of the spine and impaired mobility with functional impairment. This review will highlight the similarities and differences of these two conditions. In axSpA, the genetic background with the association with human leukocyte antigen-B27 (HLA-B27) is known for 50 years, while in DISH, a genetic contribution is not yet proven. The phenotype of new bone formation and its anatomic features are different between these diseases. In axSpA symmetric, thin and marginal syndesmophytes representing an ossification of enthesitic inflammation at the area of the attachment of the annulus fibrosus that may extend to the adjacent deeper layers anterior longitudinal ligament and are typical, while in DISH the so-called “chunky bridging osteophytes” grow as an additional layer on the anterior longitudinal ligament. Besides distinct anamnestic and clinical features, magnetic resonance imaging is helpful differentiating the two diseases since inflammatory changes with the typical pattern of axSpA are reliably visualized. Similar in both diseases is the high prevalence of vertebral fractures, which are mainly caused by the local osteoporosis and decreased flexibility of the affected bones, and therefore may occur even after minor traumata. The presence of extraarticular manifestations like uveitis, inflammatory bowel disease or psoriasis are only linked to axSpA. In contrast, DISH is associated with obesity, diabetes mellitus, and other metabolic diseases. Although DISH and axSpA are distinct conditions, the cooccurrence of these two diseases exists in some patients. Various therapeutic options are becoming available for axSpA, but no therapy has been approved for DISH yet.

David Kiefer ... Xenofon Baraliakos

Published: November 20, 2023 Explor Musculoskeletal Dis. 2023;1:194–206
DOI: https://doi.org/10.37349/emd.2023.00022
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:55

Times Cited: 1

Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axSpA) are diseases with inflammatory involvement of the axial skeleton that can result in new bone formation that may lead to total ankylosis of the spine and functional impairment of different extent in individual patients. In these diseases, the new bone formation may lead to total ankylosis of the spine and impaired mobility with functional impairment. This review will highlight the similarities and differences of these two conditions. In axSpA, the genetic background with the association with human leukocyte antigen-B27 (HLA-B27) is known for 50 years, while in DISH, a genetic contribution is not yet proven. The phenotype of new bone formation and its anatomic features are different between these diseases. In axSpA symmetric, thin and marginal syndesmophytes representing an ossification of enthesitic inflammation at the area of the attachment of the annulus fibrosus that may extend to the adjacent deeper layers anterior longitudinal ligament and are typical, while in DISH the so-called “chunky bridging osteophytes” grow as an additional layer on the anterior longitudinal ligament. Besides distinct anamnestic and clinical features, magnetic resonance imaging is helpful differentiating the two diseases since inflammatory changes with the typical pattern of axSpA are reliably visualized. Similar in both diseases is the high prevalence of vertebral fractures, which are mainly caused by the local osteoporosis and decreased flexibility of the affected bones, and therefore may occur even after minor traumata. The presence of extraarticular manifestations like uveitis, inflammatory bowel disease or psoriasis are only linked to axSpA. In contrast, DISH is associated with obesity, diabetes mellitus, and other metabolic diseases. Although DISH and axSpA are distinct conditions, the cooccurrence of these two diseases exists in some patients. Various therapeutic options are becoming available for axSpA, but no therapy has been approved for DISH yet.

Open Access

Original Article

Relationship between tendon elastography and clinical and ultrasound enthesitis scores in patients with psoriasis or psoriatic arthritis

Aim: To determine the existence of a correlation between the elastographic study of the patellar and Achilles tendons and the enthesis evaluation in patients with psoriasis with or without psoria [...] Read more.

Carlos A. Guillén-Astete ... Mónica Vázquez-Díaz

Published: November 20, 2023 Explor Musculoskeletal Dis. 2023;1:207–215
DOI: https://doi.org/10.37349/emd.2023.00023
This article belongs to the special issue Psoriatic disease: from the skin to the musculoskeletal system and beyond

Full Text

PDF

Download:24

Times Cited: 1

Open Access

Review

Diffuse idiopathic skeletal hyperostosis, beyond the musculoskeletal system

It has been suggested that diffuse idiopathic skeletal hyperostosis (DISH), a skeletal disease characterized by the ligamentous ossification of the anterolateral spine, is a radiological entity with [...] Read more.

Fabiola Atzeni ... Reuven Mader

Published: December 04, 2023 Explor Musculoskeletal Dis. 2023;1:216–227
DOI: https://doi.org/10.37349/emd.2023.00024
This article belongs to the special issue Diffuse Idiopathic Skeletal Hyperostosis- A common but neglected disease

Full Text

PDF

Download:40

Times Cited: 0

Open Access

Original Article

Impact of disease activity on patient-reported subjective cognitive decline in patients with rheumatoid arthritis

Aim: To evaluate the association of disease activity with patient-reported subjective cognitive decline (SCD) in patients with rheumatoid arthritis (RA) stratified by age. Methods: A cross- [...] Read more.

Ozlem Pala ... Joel M. Kremer

Published: December 05, 2023 Explor Musculoskeletal Dis. 2023;1:228–240
DOI: https://doi.org/10.37349/emd.2023.00025
This article belongs to the special issue Comorbidities in rheumatoid arthritis

Full Text

PDF

Download:14

Times Cited: 0