Exploration of Musculoskeletal Diseases

eGFR mls/min/1.73 m²	Allopurinol starting dose [48]	Maintenance (maximum) allopurinol dose recommendations	CrCL mls/min	Maintenance of allopurinol dose according to Hande et al. [47]
< 5	50 mg/week	Maximum dose 800 mg daily including in those with moderate to severe CKD (stage ≥ 3)	Maximum dose should be adjusted to creatinine clearance. Because the dose recommendations in renal disease may slightly differ across countries, the task force recommends following the local summary of product characteristics.	0	100 mg every three days
5–15	50 mg twice weekly	10	100 mg every two days
16–30	50 mg every two days	20	100 mg daily
31–45	50 mg daily	40	150 mg daily
46–60	50/100 mg alternate days	60	200 mg daily
> 60	100 mg daily	80	250 mg daily
-	-	100	300 mg daily
-	-	120	350 mg daily
-	-	140	400 mg daily

eGFR mls/min/1.73 m²

Allopurinol starting dose [48]

Maintenance (maximum) allopurinol dose recommendations

CrCL mls/min

Maintenance of allopurinol dose according to Hande et al. [47]

ACR 2020 gout guideline [16]

EULAR 2016 gout guideline [17]

< 5

50 mg/week

Maximum dose 800 mg daily including in those with moderate to severe CKD (stage ≥ 3)

Maximum dose should be adjusted to creatinine clearance. Because the dose recommendations in renal disease may slightly differ across countries, the task force recommends following the local summary of product characteristics.

100 mg every three days

5–15

50 mg twice weekly

100 mg every two days

16–30

50 mg every two days

100 mg daily

31–45

50 mg daily

150 mg daily

46–60

50/100 mg alternate days

200 mg daily

> 60

100 mg daily

250 mg daily

100

300 mg daily

120

350 mg daily

140

400 mg daily