Binding sites of neutralizing antibody or recombinant ACE2 in S protein
| S protein-targeted agents | Name | Binding sites in S protein | References |
|---|---|---|---|
| Neutralizing antibody | B38 | RBD: R403, D405-E406, Q409, T415-K417, D420-Y421, Y452, L454-N460, Y473-S477, F486-N487, Y489-F490, Q493-G496, Q498, T500-V503, Y505 | [231] |
| H4 | RBD | [231] | |
| BD-368-2 | RBD | [232] | |
| BD-23 | RBD: G446, Y449, L452, T470, E484-F486, Y489-F490, L492-S494, G496, Q498, T500-N501, Y505 | [232] | |
| CV30 | RBD: R403, T415-K417, D420-Y421, Y453, L455-N460, Y473-S477, F486-N487, Y489, Q493, T500, G502, Y505 | [233] | |
| EY6A | RBD: Y369, F374-S375, F377-K386, N388, L390, P412-G413, D427-F429, L517 | [234] | |
| VHH-72 | RBD: Y356-T359, F361-C366, A371-T372, G391-D392, R395, N424, I489, Y494 | [235] | |
| S309 | RBD: T333-L335, P337, G339-V341, N343-T345, K356-C361 | [236] | |
| 4A8 | NTD: R246, K150, K147, H146, W153, Y145, N149 | [237] | |
| COV57 | NTD | [238] | |
| 2-17 | NTD | [238] | |
| 5-24 | NTD | [238] | |
| LY-CoV016 | RBD: R403, D405-E406, R408-Q409, T415-K417, D420-Y421, L455-N460, Y473-S477, F486-N487, Y489, Q493, Y495, N501-G502, G504-Y505 | [230] | |
| LY-CoV555 | RBD: TYR32, ARG50, LEU55, TYR92, ARG96, TYR101, GLU102, ARG104, LEU452, GLU484, PHE486, PHE490, GLN493, SER494 | [239] | |
| REGN10933 | RBD: R403, K417, Y421, Y453, L455-F456, A475-G476, E484-Y489, Q493 | [240] | |
| REGN10987 | RBD: R346, N439-L441, K443-N450, Q498, T500 | [240] | |
| BRII-196 | RBD | [230] | |
| BRII-198 | RBD | [230] | |
| Recombinant ACE2 | APN01 | RBD | [243] |
| SBP1 | RBD | [245] |
ACE2: angiotensin-converting enzyme 2; RBD: receptor-binding domain; NTD: N-terminal domain