Exploration of Drug Science

Open Access Original Article

Study on bioactivities of Morinda citrifolia L. fruit hydroalcoholic extracts and detection of novel phytoconstituents by UPLC-Q-exactive orbitrap-tandem mass spectrum analysis

Aslee Tailulu ... Ping Shi

Published: July 24, 2025 Explor Drug Sci. 2025;3:1008121

DOI: https://doi.org/10.37349/eds.2025.1008121

This article belongs to the special issue Medicinal Plants and Their Pharmacological Properties

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Open Access Original Article

A gas chromatographic and spectrophotometric-based assessment of an oral preparation from a traditional exhilarating formulation; linking Persian medicine to the modern phytopharmaceuticals

Ali Sahragard ... Mohammad M. Zarshenas

Published: July 22, 2025 Explor Drug Sci. 2025;3:1008120

DOI: https://doi.org/10.37349/eds.2025.1008120

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Open Access Mini Review

The dual role of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: mechanisms, clinical relevance, and therapeutic opportunities

Houhong Wang, Shang Bian

Published: July 22, 2025 Explor Drug Sci. 2025;3:1008119

DOI: https://doi.org/10.37349/eds.2025.1008119

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Open Access Review

Prominent events in the development of a simultaneous multidiagnostic system with synthetic peptides

Oscar Noya ... Sandra Losada

Published: July 17, 2025 Explor Drug Sci. 2025;3:1008118

DOI: https://doi.org/10.37349/eds.2025.1008118

This article belongs to the special issue Bioactive Peptides discovery and development

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Open Access Review

Inflammatory bowel disease in Africa: the current landscape of pharmacological treatments and the promise of emerging innovations

Murtada A. Oshi

Published: July 10, 2025 Explor Drug Sci. 2025;3:1008117

DOI: https://doi.org/10.37349/eds.2025.1008117

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Open Access Review

Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024)

Hassan Aliashrafzadeh ... Da Zhi Liu

Published: July 01, 2025 Explor Drug Sci. 2025;3:1008116

DOI: https://doi.org/10.37349/eds.2025.1008116

This article belongs to the special issue Leveraging the FDA-Approved Kinase Inhibitors to Treat Neurological Disorders

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Open Access Original Article

A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

Iftekhar Mahmood

Published: July 01, 2025 Explor Drug Sci. 2025;3:1008115

DOI: https://doi.org/10.37349/eds.2025.1008115

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Open Access Review

Erythrocyte binding peptides: a story in the search for a malaria vaccine

Mauricio Urquiza-Martinez ... Fanny Guzmán-Quimbayo

Published: June 25, 2025 Explor Drug Sci. 2025;3:1008114

DOI: https://doi.org/10.37349/eds.2025.1008114

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Open Access Original Article

Interaction of brequinar and analogs with PD-L1: a molecular docking analysis

Gérard Vergoten, Christian Bailly

Published: June 09, 2025 Explor Drug Sci. 2025;3:1008113

DOI: https://doi.org/10.37349/eds.2025.1008113

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Open Access Review

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application

Dmitrii Platov ... Mikhail Drenichev

Published: May 29, 2025 Explor Drug Sci. 2025;3:1008112

DOI: https://doi.org/10.37349/eds.2025.1008112

This article belongs to the special issue Bioactive Molecules from Natural Sources

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Open Access Original Article

Cytochrome P450 2C9-mediated interactions: molecular docking studies of natural anti-arthritic compounds

Boon Hooi Tan ... Chin Eng Ong

Published: May 27, 2025 Explor Drug Sci. 2025;3:1008111

DOI: https://doi.org/10.37349/eds.2025.1008111

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Open Access Review

Antimicrobial peptides: structure, function, mechanism of action and therapeutic applications in human diseases

Rahul Dilawari ... Neha Parmar

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008110

DOI: https://doi.org/10.37349/eds.2025.1008110

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Open Access Original Article

High-risk neuroblastoma stage 4 (NBS4): multi-target inhibitors for c-Src kinases (Csk) and retinoic acid (RA) signalling pathways

Amgad Gerges, Una Canning

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008109

DOI: https://doi.org/10.37349/eds.2025.1008109

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Open Access Original Article

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics

Navya Aggarwal ... Banashree Bondhopadhyay

Published: April 29, 2025 Explor Drug Sci. 2025;3:1008108

DOI: https://doi.org/10.37349/eds.2025.1008108

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Open Access Original Article

Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids

David Chafi Zeitune ... Camilla Djenne Buarque

Published: April 21, 2025 Explor Drug Sci. 2025;3:1008107

DOI: https://doi.org/10.37349/eds.2025.1008107

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Open Access Review

Natural products targeting cancer stem cells: a promising therapeutic approach

Julia K. Opara ... Shrikant Anant

Published: April 18, 2025 Explor Drug Sci. 2025;3:1008106

DOI: https://doi.org/10.37349/eds.2025.1008106

This article belongs to the special issue Remedial benefits of natural products in inflammation and cancer

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Open Access Review

A narrative review on the role of gut microbiome, dietary strategies, and supplements in managing metabolic syndrome

Sunil Chopra ... Ramendra Pati Pandey

Published: April 14, 2025 Explor Drug Sci. 2025;3:1008105

DOI: https://doi.org/10.37349/eds.2025.1008105

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Open Access Original Article

Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds

Lakshmi Mounika Kelam ... M. Elizabeth Sobhia

Published: April 10, 2025 Explor Drug Sci. 2025;3:1008104

DOI: https://doi.org/10.37349/eds.2025.1008104

This article belongs to the special issue Bioactive Molecules from Natural Sources

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Open Access Review

The use of peptides for deciphering the mechanism of EBV, HPV, and HCV invasion of human cells

Daniela Perdomo-Joven ... Mauricio Urquiza-Martinez

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008103

DOI: https://doi.org/10.37349/eds.2025.1008103

This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research

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Open Access Review

Novel progression on clinical therapy of COVID-19: Western and Traditional Chinese Medicines

Yongjia Xiong ... Feiyue Xing

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008102

DOI: https://doi.org/10.37349/eds.2025.1008102

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