Exploration of Drug Science

Open Access Review

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application

Dmitrii Platov ... Mikhail Drenichev

Published: May 29, 2025 Explor Drug Sci. 2025;3:1008112

DOI: https://doi.org/10.37349/eds.2025.1008112

This article belongs to the special issue Bioactive Molecules from Natural Sources

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Open Access Original Article

Cytochrome P450 2C9-mediated interactions: molecular docking studies of natural anti-arthritic compounds

Boon Hooi Tan ... Chin Eng Ong

Published: May 27, 2025 Explor Drug Sci. 2025;3:1008111

DOI: https://doi.org/10.37349/eds.2025.1008111

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Open Access Review

Antimicrobial peptides: structure, function, mechanism of action and therapeutic applications in human diseases

Rahul Dilawari ... Neha Parmar

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008110

DOI: https://doi.org/10.37349/eds.2025.1008110

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Open Access Original Article

High-risk neuroblastoma stage 4 (NBS4): multi-target inhibitors for c-Src kinases (Csk) and retinoic acid (RA) signalling pathways

Amgad Gerges, Una Canning

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008109

DOI: https://doi.org/10.37349/eds.2025.1008109

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Open Access Original Article

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics

Navya Aggarwal ... Banashree Bondhopadhyay

Published: April 29, 2025 Explor Drug Sci. 2025;3:1008108

DOI: https://doi.org/10.37349/eds.2025.1008108

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Open Access Original Article

Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids

David Chafi Zeitune ... Camilla Djenne Buarque

Published: April 21, 2025 Explor Drug Sci. 2025;3:1008107

DOI: https://doi.org/10.37349/eds.2025.1008107

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Open Access Review

Natural products targeting cancer stem cells: a promising therapeutic approach

Julia K. Opara ... Shrikant Anant

Published: April 18, 2025 Explor Drug Sci. 2025;3:1008106

DOI: https://doi.org/10.37349/eds.2025.1008106

This article belongs to the special issue Remedial benefits of natural products in inflammation and cancer

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Open Access Review

A narrative review on the role of gut microbiome, dietary strategies, and supplements in managing metabolic syndrome

Sunil Chopra ... Ramendra Pati Pandey

Published: April 14, 2025 Explor Drug Sci. 2025;3:1008105

DOI: https://doi.org/10.37349/eds.2025.1008105

This article belongs to the special issue Preventive and Therapeutic Potential of Nutraceuticals in Non-communicable Diseases

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Open Access Original Article

Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds

Lakshmi Mounika Kelam ... M. Elizabeth Sobhia

Published: April 10, 2025 Explor Drug Sci. 2025;3:1008104

DOI: https://doi.org/10.37349/eds.2025.1008104

This article belongs to the special issue Bioactive Molecules from Natural Sources

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Open Access Review

The use of peptides for deciphering the mechanism of EBV, HPV, and HCV invasion of human cells

Daniela Perdomo-Joven ... Mauricio Urquiza-Martinez

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008103

DOI: https://doi.org/10.37349/eds.2025.1008103

This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research

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Open Access Review

Novel progression on clinical therapy of COVID-19: Western and Traditional Chinese Medicines

Yongjia Xiong ... Feiyue Xing

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008102

DOI: https://doi.org/10.37349/eds.2025.1008102

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382 15 0

Open Access Review

Folic acid conjugated with serum albumin for nano- and submicron delivery systems for applications in therapy and diagnostics

Maria G. Gorobets ... Anna V. Bychkova

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008101

DOI: https://doi.org/10.37349/eds.2025.1008101

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447 13 0

Open Access Original Article

Efficacy of propolis varnish in reducing Streptococcus mutans counts

Mariana Passos De Luca ... Vagner Rodrigues Santos

Published: March 20, 2025 Explor Drug Sci. 2025;3:100899

DOI: https://doi.org/10.37349/eds.2025.100899

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381 13 1

Open Access Review

Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs

Tatiana Gudasheva ... Vladimir Dorofeev

Published: March 21, 2025 Explor Drug Sci. 2025;3:1008100

DOI: https://doi.org/10.37349/eds.2025.1008100

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384 8 0

Open Access Review

Molecular mechanisms and therapeutic prospects of 4-aminobenzoic acid in neuropsychiatric disorders: a comprehensive review of neurotransmitter modulation, anti-inflammatory pathways, and antioxidant defense

Siyu Chen ... Yangyang Liu

Published: March 19, 2025 Explor Drug Sci. 2025;3:100898

DOI: https://doi.org/10.37349/eds.2025.100898

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283 7 0

Open Access Review

Multidrug resistance and major facilitator superfamily antimicrobial efflux pumps of the ESKAPEE pathogen Staphylococcus aureus

Ebenezer Aborah ... Manuel F. Varela

Published: March 19, 2025 Explor Drug Sci. 2025;3:100897

DOI: https://doi.org/10.37349/eds.2025.100897

This article belongs to the special issue Discovery and development of new antibacterial compounds

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Open Access Retraction

Retraction: Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies

Juan Manuel Galdopórpora ... María Victoria Tuttolomondo

Published: March 17, 2025 Explor Drug Sci. 2025;3:100896

DOI: https://doi.org/10.37349/eds.2025.100896

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Open Access Original Article

Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies

Juan Manuel Galdopórpora ... María Victoria Tuttolomondo

Published: February 28, 2025 Explor Drug Sci. 2025;3:100895

DOI: https://doi.org/10.37349/eds.2025.100895

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469 28 0

Open Access Original Article

Prediction of drug exposure in hepatic impairment: a comparison between minimal physiologically based pharmacokinetic (mPBPK) and whole body PBPK models

Iftekhar Mahmood

Published: February 27, 2025 Explor Drug Sci. 2025;3:100894

DOI: https://doi.org/10.37349/eds.2025.100894

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370 18 0

Open Access Review

Critical review on nutritional, bioactive and medicinal potential of Bunium persicum

Prachi Bhatt ... Mamta Baunthiyal

Published: February 27, 2025 Explor Drug Sci. 2025;3:100893

DOI: https://doi.org/10.37349/eds.2025.100893

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505 11 0