From:  Electrospun short fibers: a new platform for cancer nanomedicine applications

Summary of platforms for tumor diagnosis and treatment with representative electrospun SFs

ApplicationPlatformsMethodCell modelsMechanism of actionReferences
CTC captureFe3O4@PEI/PVA-Apt SFsHomogenization treatmentMCF-7 cellsDNA Apt-based ligand-receptor binding to capture breast cancer cells in vitro[23]
Tumor therapyPDA-PLA SFsCutting and filteringB16F10/T cellsImmunotherapy of melanoma[10]
Coumarin-PELA containing fiber rodsUltrasonication treatment4T1 and RAW 264.7Chemotherapy of breast cancer[36]
DOX@LDH/α-TOS/PLGA SFsHomogenization treatmentMCF-7/ADR cellsChemotherapy of breast cancer cells in vitro[39]
Tumor theranosticsDOX@PLGA-PEI-Gd/AptHomogenization treatment4T1 tumor cellsChemotherapy and MR imaging of breast cancer[40]
DOX-PLGA-PEI-DTPA-Gd/HA fiber microspheresHomogenization treatment4T1 tumor cellsChemotherapy and MR imaging of breast cancer[41]
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Apt: aptamer; DOX: doxorubicin; DTPA: diethylenetriaminepentaacetic dianhydride; Gd: gadolinium; HA: hyaluronic acid; LDH: layered double hydroxide; MR: magnetic resonance; PDA: polydopamine; PEI: polyethylenimine; PELA: polyethylene glycol PLA; PVA: polyvinyl alcohol; α-TOS: α-tocopheryl succinate