The comparison properties of three classes of therapeutic molecules
| Properties | Small molecules | Stapled peptides | Biologics |
|---|---|---|---|
| Molecular weight | < 1,000 | 1,000–5,000 | > 10,000 |
| Stability | High | High | Low |
| Binding affinity | Low | High | High |
| Specificity | Low | High | High |
| Cellular permeability | High | High | Low |
| Proteolysis resistance | High | High | Low |
| Toxicity/side effects | High | Low | Low |
| Ability to disrupt PPIs | Low | High | High |
| Manufacturing cost | Low | Low | High |