Exploration of Drug Science

Table 4

Changes in organ coefficients (%) in SD rats during subacute toxicity studies for 30 days

Rats	Organs	Control	Free ISL	Excipient	ISL@ZLH NPs
Rats	Organs	Control	Free ISL	Excipient	27.5 mg/kg	55.0 mg/kg	110.0 mg/kg
Male	Heart	0.357 ± 0.016	0.371 ± 0.033	0.357 ± 0.008	0.359 ± 0.007	0.375 ± 0.020	0.371 ± 0.022
	Thyroid	0.012 ± 0.001	0.011 ± 0.001	0.012 ± 0.001	0.013 ± 0.001	0.012 ± 0.001	0.012 ± 0.001
	Spleen	0.232 ± 0.020	0.222 ± 0.022	0.228 ± 0.008	0.241 ± 0.026	0.224 ± 0.027	0.228 ± 0.032
	Liver	2.631 ± 0.072	2.606 ± 0.161	2.527 ± 0.068	2.575 ± 0.116	2.564 ± 0.058	2.497 ± 0.086
	Kidneys	0.549 ± 0.011	0.550 ± 0.008	0.536 ± 0.017	0.547 ± 0.003	0.554 ± 0.017	0.546 ± 0.012
	Adrenals	0.019 ± 0.001	0.019 ± 0.001	0.018 ± 0.001	0.018 ± 0.001	0.019 ± 0.000	0.019 ± 0.000
	Prostate	0.122 ± 0.004	0.126 ± 0.005	0.126 ± 0.010	0.123 ± 0.002	0.119 ± 0.004	0.124 ± 0.009
	Testes	0.647 ± 0.012	0.657 ± 0.016	0.641 ± 0.027	0.658 ± 0.013	0.652 ± 0.015	0.660 ± 0.010
Female	Heart	0.350 ± 0.013	0.375 ± 0.020	0.366 ± 0.015	0.374 ± 0.019	0.390 ± 0.036	0.372 ± 0.043
	Thyroid	0.010 ± 0.005	0.012 ± 0.001	0.012 ± 0.001	0.013 ± 0.001	0.013 ± 0.001	0.013 ± 0.001
	Spleen	0.224 ± 0.027	0.232 ± 0.043	0.226 ± 0.024	0.204 ± 0.018	0.220 ± 0.033	0.227 ± 0.027
	Liver	2.518 ± 0.168	2.500 ± 0.114	2.603 ± 0.101	2.451 ± 0.109	2.609 ± 0.080	2.563 ± 0.106
	Kidneys	0.553 ± 0.013	0.549 ± 0.010	0.534 ± 0.045	0.572 ± 0.029	0.553 ± 0.012	0.551 ± 0.005
	Adrenals	0.018 ± 0.001	0.019 ± 0.001	0.020 ± 0.002	0.021 ± 0.003	0.018 ± 0.001	0.019 ± 0.001
	Ovaries	0.236 ± 0.010	0.248 ± 0.015	0.222 ± 0.013	0.224 ± 0.016	0.228 ± 0.011	0.230 ± 0.016
	Uterus	0.053 ± 0.001	0.055 ± 0.001	0.054 ± 0.004	0.053 ± 0.001	0.050 ± 0.002	0.055 ± 0.005

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Values are expressed as mean ± standard deviation, n = 5. The Dunnett t-test was used to determine the significance of data variability between the treated and control groups. Statistical significance was considered at ^*P < 0.05