Exploration of Drug Science

Table 5

Changes in organ coefficients (%) in SD rats during subacute toxicity studies for 90 days

Rats	Organs	Control	Free ISL	Excipient	ISL@ZLH NPs
Rats	Organs	Control	Free ISL	Excipient	27.5 mg/kg	55.0 mg/kg	110.0 mg/kg
Male	Heart	0.316 ± 0.004	0.319 ± 0.011	0.317 ± 0.008	0.323 ± 0.010	0.320 ± 0.007	0.331 ± 0.015
	Thyroid	0.111 ± 0.001	0.107 ± 0.001	0.111 ± 0.004	0.109 ± 0.002	0.108 ± 0.002	0.111 ± 0.002
	Spleen	0.181 ± 0.008	0.179 ± 0.008	0.181 ± 0.012	0.182 ± 0.007	0.188 ± 0.002	0.188 ± 0.002
	Liver	2.358 ± 0.037	2.320 ± 0.076	2.347 ± 0.084	2.257 ± 0.083	2.360 ± 0.020	2.277 ± 0.092
	Kidneys	0.523 ± 0.013	0.513 ± 0.008	0.521 ± 0.005	0.517 ± 0.009	0.520 ± 0.011	0.512 ± 0.012
	Adrenals	0.021 ± 0.001	0.020 ± 0.001	0.021 ± 0.001	0.021 ± 0.001	0.020 ± 0.001	0.020 ± 0.001
	Prostate	0.101 ± 0.003	0.102 ± 0.006	0.101 ± 0.007	0.101 ± 0.002	0.099 ± 0.010	0.101 ± 0.005
	Testes	0.619 ± 0.008	0.635 ± 0.027	0.636 ± 0.026	0.638 ± 0.014	0.620 ± 0.000	0.642 ± 0.013
Female	Heart	0.329 ± 0.012	0.332 ± 0.023	0.328 ± 0.005	0.319 ± 0.004	0.337 ± 0.008	0.339 ± 0.010
	Thyroid	0.110 ± 0.004	0.110 ± 0.003	0.112 ± 0.005	0.110 ± 0.003	0.109 ± 0.004	0.109 ± 0.004
	Spleen	0.172 ± 0.002	0.176 ± 0.004	0.174 ± 0.005	0.177 ± 0.004	0.173 ± 0.003	0.178 ± 0.008
	Liver	2.343 ± 0.091	2.411 ± 0.083	2.312 ± 0.124	2.345 ± 0.063	2.355 ± 0.148	2.326 ± 0.150
	Kidneys	0.517 ± 0.016	0.525 ± 0.011	0.515 ± 0.006	0.509 ± 0.026	0.510 ± 0.017	0.515 ± 0.010
	Adrenals	0.020 ± 0.001	0.020 ± 0.001	0.021 ± 0.001	0.020 ± 0.000	0.020 ± 0.003	0.021 ± 0.002
	Ovaries	0.206 ± 0.004	0.192 ± 0.002	0.207 ± 0.007	0.207 ± 0.009	0.203 ± 0.010	0.208 ± 0.005
	Uterus	0.046 ± 0.001	0.044 ± 0.002	0.043 ± 0.001	0.044 ± 0.003	0.046 ± 0.002	0.044 ± 0.002

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Values are expressed as mean ± standard deviation, n = 5. The Dunnett t-test was used to determine the significance of data variability between the treated and control groups. Statistical significance was considered at ^*P < 0.05