Changes in the hematological parameters of SD rats in subacute toxicity studies for 90 days
| Rats | Organs | Control | Free ISL | Excipient | ISL@ZLH NPs | ||
|---|---|---|---|---|---|---|---|
| 27.5 mg/kg | 55.0 mg/kg | 110.0 mg/kg | |||||
| Male | RBC (× 1012/L) | 7.39 ± 0.13 | 7.29 ± 0.12 | 7.34 ± 0.14 | 7.30 ± 0.18 | 7.24 ± 0.15 | 7.31 ± 0.10 |
| WBC (× 109/L) | 11.94 ± 0.38 | 11.81 ± 0.42 | 11.91 ± 0.66 | 11.81 ± 0.48 | 11.49 ± 0.62 | 12.03 ± 0.68 | |
| Hb (g/L) | 214.45 ± 4.93 | 213.00 ± 4.81 | 219.44 ± 2.95 | 218.78 ± 3.60 | 218.95 ± 6.26 | 218.39 ± 6.58 | |
| HCT (%) | 45.99 ± 1.07 | 45.59 ± 0.81 | 45.57 ± 1.06 | 45.35 ± 0.40 | 45.92 ± 1.34 | 45.70 ± 1.02 | |
| GLU (mmol/L) | 9.76 ± 0.29 | 9.80 ± 0.25 | 9.53 ± 0.20 | 9.53 ± 0.37 | 9.85 ± 0.08 | 9.86 ± 0.23 | |
| BUN (mmol/L) | 5.82 ± 0.31 | 5.78 ± 0.36 | 5.82 ± 0.25 | 5.86 ± 0.48 | 5.70 ± 0.14 | 5.77 ± 0.41 | |
| SGPT (U/L) | 51.76 ± 5.27 | 53.72 ± 2.28 | 54.08 ± 3.81 | 51.98 ± 4.69 | 53.40 ± 4.78 | 52.28 ± 3.51 | |
| PT (s) | 12.52 ± 0.33 | 12.46 ± 0.34 | 12.32 ± 0.32 | 12.50 ± 0.35 | 12.38 ± 0.40 | 12.28 ± 0.37 | |
| Female | RBC (× 1012/L) | 7.19 ± 0.16 | 7.30 ± 0.24 | 7.35 ± 0.14 | 7.27 ± 0.16 | 7.23 ± 0.23 | 7.19 ± 0.19 |
| WBC (× 109/L) | 11.58 ± 0.49 | 11.78 ± 0.92 | 12.34 ± 0.34 | 11.60 ± 0.45 | 12.14 ± 0.43 | 11.64 ± 0.26 | |
| Hb (g/L) | 213.53 ± 4.30 | 215.77 ± 4.55 | 212.99 ± 3.78 | 217.18 ± 5.77 | 211.75 ± 7.59 | 215.57 ± 3.75 | |
| HCT (%) | 46.59 ± 0.53 | 46.09 ± 0.99 | 45.84 ± 0.83 | 46.16 ± 0.80 | 46.56 ± 0.65 | 46.11 ± 1.36 | |
| GLU (mmol/L) | 9.68 ± 0.17 | 9.61 ± 0.27 | 9.82 ± 0.25 | 9.77 ± 0.33 | 9.62 ± 0.20 | 9.52 ± 0.19 | |
| BUN (mmol/L) | 5.80 ± 0.30 | 5.96 ± 0.39 | 5.82 ± 0.33 | 5.92 ± 0.25 | 5.54 ± 0.25 | 5.86 ± 0.38 | |
| SGPT (U/L) | 52.78 ± 3.25 | 52.48 ± 3.51 | 52.00 ± 3.95 | 52.24 ± 2.54 | 54.92 ± 4.77 | 56.06 ± 2.87 | |
| PT (s) | 12.58 ± 0.40 | 12.30 ± 0.35 | 12.62 ± 0.26 | 12.92 ± 0.69 | 12.86 ± 0.21 | 12.44 ± 0.40 | |
Values are expressed as mean ± standard deviation, n = 5. The Dunnett t-test was used to determine the significance of data variability between the treated and control groups. Statistical significance was considered at *P < 0.05