Exploration of Drug Science

Table 1

Summary of autophagy inducers (AI) and senescence inhibitors (SI) along with their potential target mechanisms

Compounds		Target/mechanism	References
AI	Resveratrol	Sirtuin-1	[53]
	Quercetin	Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
	Plant lectin	Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
	Trehalose	Antioxidant and more	[54]
	Cyclo-trijuglone of Juglans regia L.	Inhibitor of mTOR	[12]
	Resveratrol	Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
	Paclitaxel	Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
	Oridonin	Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
SI	Curcumin	Anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties	[55]
	Quercetin	Selectively clear senescent cells; reduce senescence-associated secretory phenotype (SASP); Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53	[26]
	Fisetin	Selectively clear senescent cells; reduce SASP	[8, 14]
	Dasatinib	Selectively clear senescent cells	[8]
	Navitoclax	Selectively clear senescent cells	[8]