Cytotoxic and selective effect of RWQWRWQWR peptide and peptides functionalized with the RGD motif
| Code | Peptide | IC50, µg/mL (µM) | Selectivity index | Hemolysis (%)a | |
|---|---|---|---|---|---|
| MCF-7 | Fibroblasts | ||||
| 1R5R9R | RWQWRWQWR | 120 (81) | > 200 (135)* | > 1.6 | 6.7 |
| 14 | RGD-Ahx-RWQWRWQWR | 27 (14) | 108 (56) | 4.0 | 7.1 |
| R1R5R9R | RRWQWRWQWR | 112 (68) | > 200 (121)* | > 1.8 | 6.4 |
| 19 | RGD-Ahx-RRWQWRWQWR | 82 (39) | 195 (94) | 2.4 | 2.0 |
a Percentage of hemolysis calculated at the maximum concentration (200 µg/mL). *: IC50 could not be calculated because at the maximum concentration, there was no reduction in viability by 50%; IC50: half maximal inhibitory concentration