Epitopes identified in Latin American snake toxins
| Venom animal | Toxin(UniProt) | Epitope | Epitope mapping | Immunogen | Reference |
|---|---|---|---|---|---|
| Bothrops neuwiedi | SVMP neuwiedase (Q9I9R4) | NTXNGFFRSXN, HNLGMEHDGKDXL | Phage display | Peptides displayed on phages | [43] |
| Bothrops atrox | SVMP atroxlysin-1 (P85420) | NGNSDKIRRRIH-GG-GVEIWSNKDLINVQ | Spotsynthesis | Peptide in liposomes | [32] |
| Bothrops atrox | SVMP atroxlysin-1 (P85420) | V9DLFIVVDHGMFMKY23 | Informatic | Peptide in liposomes | [50] |
| Bothrops jararaca | SVMP bothropasin, (O93523) | K202ARMYELANIVNEILRYLYMH222 | Spot synthesis | Polymerized peptide | [33] |
| Lachesis muta | SVMP hemorrhagic factor 2, (P22796) | QCTMDQGRLRCR, TCATDQGRLRCT, HCFHDQGRVRCA, HCTMDQGRLRCR, SCMLDQGRSRCR | Phage display | Peptides in liposomes | [44] |
| Lachesis muta | SVMP hemorrhagic factor 2, (P22796) | PYCQCLNKPYL | Informatic | Peptide in liposomes | [51] |
| Lachesis stenophrys | SVSP (Q072L7) | W54VLTAAHCDR74, K109DKDIMLIKLDSPVSNS123, L193EGGKDSCKGDSGGPLI209 | Informatic | Individual peptides | [52] |
| Crotalus durissus terrificus | PLA2 crotoxin basic subunit, (P62022) | L10LVGVEGHLLQFNKMIKFETR30, Y43CGWGGRGRPKDATDRCCFVH63, T118YKYGYMFYPDSRCRGPSETC138 | Spot synthesis | Peptides in liposomes | [34] |
| Crotamine (Q9PWF3) | F12PKEKICLPPSSDFGKMDCRW32 | ||||
| Micrurus corallinus | PLA2 (Q8AXW7) | N28LINFQRMIQCTTRRSAW45, N119CDRTAALCFGRAPYNKNN137 | Spot synthesis | Polymerized peptides | [35] |
| 3FTX (C6JUP3 and others) | P39DDFTCVKKWEGGGRRV55, T37CPAGQKICFKKWKKG52, P64KPKKDETIQCCTKNN79, L22ECKICNFKTCPTDELRH39, T54HRGLRIDRGCAATCPTVK72, R28HASDSQTTTCLSGICYKK45, G58CPQSSRGVKVDCCMRDK75 |
SVMP: snake venom metalloproteinase; SVSP: snake venom serine protease; PLA2: phospholipase A2; 3FTx: three-finger toxin; X: any one of the 20 amino acids