Epitopes identified in Latin American spider toxins
Venom animal | Toxin (UniProt) | Peptide epitope | Epitope mapping | Immunogen | Reference |
---|---|---|---|---|---|
Loxosceles intermedia | LiD1 (P0CE81) | M13VNAIGQIDEFVNLG27, I31ETDVSFDDNANPEY45, S58KKYENFNDFLKGLR72, D100NQANDAGKKLAKNL114, D160KVGHDFSGNDDISD174, N247YPDVITDVLNEAAY261 | Spot synthesis | Peptide mixture with or without rLiD1 | [39] |
Loxosceles intermedia | LiD1 (P0CE81) | N25LGANSIETDVSFDDNANPEYTYHGIP51 | Spot synthesis | Peptide | [40] |
Loxosceles intermedia | LiD1 (P0CE81) | NCNKNDHLFACW, NSNKNDHLFASW | Phage display | Peptide in liposomes | [45] |
Phoneutria nigriventer | δ-ctenitoxin-Pn2a (P29425) | GYFWIAWYKLAN-Abu-KKG | Informatic | Branched or palmitoylated peptide | [22] |
Abu: α-aminobutyric acid; LiD1: Loxosceles intermedia dermonecrotic protein 1; rLiD1: recombinant Loxosceles intermedia dermonecrotic protein 1