Exploration of Drug Science

Table 4

Predicted and observed clearance values in children

Medicines	Age	Observed clearance (mL/min)		Predicted clearance (mL/min)		Ratio = predicted/observed
Medicines	Age	IV	Oral	IV	Oral	IV	Oral
Midazolam	Adult	323	763	NA	NA	NA	NA
	Preterm	1.8	2.9	2.0	5.2	1.10	1.80
	0.5–2 years	52	286	36	85	0.69	0.30
	5.5–6 years	159	585	114	270	0.72	0.46
Famotidine	Adult	463	1,030	NA	NA	NA	NA
	11–15 years	400	718	360	800	0.90	1.11
	0–1 year	55	131	66	147	1.20	1.12
Voriconazole	Adult	254	323	NA	NA	NA	NA
	2–<6 years	102	232	92	117	0.90	0.50
	6–<12 years	171	279	137	174	0.80	0.62
Diclofenac	Adult	263	499	NA	NA	NA	NA
Diclofenac	1–12 years	153	218	103	173	0.67	0.79
Cyclosporine	Adult	317	1,683	NA	NA	NA	NA
Cyclosporine	1.1–2.5 years	113	518	57	305	0.51	0.59
Cefetamet	Adult	155	399	NA	NA	NA	NA
	3–7 years	50	230	54	138	1.07	0.60
	>7–12 years	79	393	94	242	1.19	0.62
	3.5–17 months	18	48	21	54	1.16	1.12
Zidovudine	Adult	1,377	1,832	NA	NA	NA	NA
	Term < 14 days	22	32	28	37	1.25	1.15
	Term > 14 days	76	85	76	101	0.99	1.18
Azithromycin	Adult	817	1,910	NA	NA	NA	NA
	0.5–2 years	166	606	118	306	0.71	0.50
	>2–5 years	280	749	214	480	0.76	0.64
	7–12 years	624	1,191	527	1,172	0.84	0.98
Busulfan	Adult	175	240	NA	NA	NA	NA
Busulfan	1.4–6 years	57	99	58	79	1.01	0.80
Cimetidine	Adult	495	840	NA	NA	NA	NA
Cimetidine	4–13 years	302	559	236	400	0.78	0.71
Digoxin	Adult	192	262	NA	NA	NA	NA
Digoxin	Infants	39	55	8	11	0.21	0.20
Clonidine	Adult	260	292	NA	NA	NA	NA
Clonidine	3–10 years	85	155	102	114	1.20	0.74
Ranitidine	Adult	677	1,485	NA	NA	NA	NA
Ranitidine	3.5–16 years	568	1,183	526	1,154	0.93	0.98
Ketoprofen	Adult	83	90	NA	NA	NA	NA
	7–93 months	23	30	32	35	1.41	1.17
	0.5–2 years	12	15	12	13	0.99	0.86
	>2–7 years	22	32	31	34	1.42	1.06
Itraconazole	Adult	337	1,762	NA	NA	NA	NA
	0.5–2 years	173	541	44	219	0.25	0.40
	>2–5 years	160	465	123	563	0.76	1.21
	>5–12 years	298	991	173	787	0.58	0.79

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For clearances same references as of absolute bioavailability. IV: intravenous; NA: not available