From:  Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer

Summary of studies demonstrating crosstalks between the PTEN and PAFR as well as PAFR and EGFR pathways

Cancer modelCell line(s)Treatment(s)Key findingsReference
Breast cancerMCF-7, MDA-MB-231PAFR antagonistPAFR antagonist-mediated decreased invasive behavior and G0/G1 cell cycle arrest was mediated via increased PTEN expression[29]
MelanomaB16F10Ad-PTENAd-PTEN blocked PAF-induced pulmonary melanoma metastasis[31]
Ovarian cancerOVCA 429, OVCA 432PAFR antagonistPAFR antagonist blocked PAF-induced activation of EGFR and downstream signaling cascades resulting in decreased cell proliferation[34]
Ovarian cancerSKOV3-PAF-PAFR signaling induced increased EGFR activation[35]
Ovarian cancerCAOV3, SKOV3PAFR antagonist and EGFR inhibitorIncreased inhibition of cell proliferation and invasion and decreased tumor growth[36]
Ovarian cancerCAOV3, SKOV3PAFR antagonist and EGFR inhibitorInhibition of the PAFR and EGFR blocked EGF-induced PAF production[37]
Epidermal cellsKBEGFR inhibitorInhibition of increased production of PAFR agonists and systemic immunosuppression[38]
Ovarian cancerCASKI, C33APAFR antagonist and EGFR inhibitorDecreased cell viability and proliferation[39]
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PTEN: phosphatase and tensin homolog; PAFR: platelet-activating factor-receptor; EGFR: epidermal growth factor receptor; Ad-PTEN: adenovirus harboring cDNA construct of PTEN; -: no data