From:  Advantages of using biofilms to obtain high-value molecules by microbial biotransformations

Compilation of ten years (2013–2023) of published studies concerning microbial biotransformations conducted by biofilms to produce high-value molecules

GroupStrainParental molecule(s)Daughter molecule(s)UseScaffoldReference
FungiCandida viswanathii NBRC10321CitronellalCitronellic acidIngredient used in perfumesMicrospheres of PMMA[60]
Cunninghamella echinulata ATCC9244HesperetinHesperetin 7-O-glycosideArome of sweet orangeStainless steel wool[61]
Cunninghamella echinulata ATCC9244LQFM-021N-glycosylated LQFM-021Phosphodiesterase-3 inhibitorStainless steel mesh[62]
Cunninghamella elegans DSM1908Diclofenac4’-HydroxydiclofenacCox-2 inhibitorStainless steel springs[63]
Cunninghamella elegans DSM1908Diclofenac4’-HydroxydiclofenacCox-2 inhibitorStainless steel mesh[57]
Cunninghamella elegans DSM1908Flurbiprofen4-HydroxyflurbiprofenStandart for purity assaysStainless steel springs[64]
Lasiodiplodia (Botryodiplodia) theobromae 1368(+)-Valencene(+)-NootkatoneArome of grapefruitPermeable silicon rubber[65]
Mucor circinelloides URM4182Babassu oil lipidesEthyl esters (various)Diverse applicationsPolyurethane foams[66]
Pichia kluyveri NBRC1165CitronellolCitronellyl acetateMosquito repellentMicrospheres of PMMA[60]
Yarrowia lipolytica W29 (ATCC 20460)Methylricinoleate3-Hydroxy-γ-decalactoneAromatic compoundGroupons of PMMA[67]
BacteriaLactobacillus brevis RK03Monosodium glutamateγ-Aminobutyric acid (GABA)Anti-seizure and anti-anxiety drugGroupons of HEMA/PEGDA[68]
Bacillus subtilis BS-7Ferulic acidVanilinAromatic compoundCarbon fiber textiles[69]
Bacillus subtilis BS-7 SFerulic acidVanilinAromatic compoundActive carbon fiber[70]
Escherichia coli BL215-Nitrononane-2,8-dione(R)-syn/anti-hydroketoneDiverse applicationsPDMS[71]
Escherichia coli BL21(DE3)IndoleTryptophanAmino acidCellulose sponge [72]
Escherichia coli MG16555-Haloindole5-HalotryptophanPharmaceutical intermediaryGlass slides with poly-L-lysine[73]
Pseudomonas diminuta ATCC19146Ethylene glycolGlycolic acidAnti-aging agentStainless steel structured packing[74]
Pseudomonas putida GS1(R)-(+)-Limonene(R)-(+)-Perillic acidAntineoplastic agentSilicon membrane[75]
Pseudomonas taiwanensis VLB120 B83 T7Glucose(S)-3-Hydroxyisobutyric acidIntermediate in the metabolism of valineSilicon tubing[75]
Rhodococcus hoagii NBRC37302-Octanol2-OctanoneIngredient used in perfumesMicrospheres of PMMA[76]
AssociationsSynechocystis sp. PCC 6803 plusCyclohexaneCyclohexanolPlasticizer agentBorosilicate glass[77]
Pseudomonas sp. VLB120[78]
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LQFM-021: 5-(1-(3-Fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole; PMMA: methyl-polymethacrylate; HEMA/PEGDA: hydroxyethyl methacrylate/polyethylene glycol diacrylate; PDMS: polydimethylsiloxane