Presence of pain and pain intensity [on visual analog scale (VAS) from 0: no pain to 10: the strongest possible pain] in participants experiencing presence of pain. The lysozyme group was treated with a spray containing lysozyme hydrochloride + cetylpyridinium chloride + lidocaine, control group was treated with a compounded preparation containing gentamicin sulfate + dexamethasone + lidocaine
| Visit | Parameter | All participants(n = 56) | Lysozyme group(n = 26) | Control group(n = 30) | p-value lysozyme vs. control group |
|---|---|---|---|---|---|
| Eating solid food | |||||
| Baseline | Presence of pain | 52 (93) | 23 (88) | 29 (97) | 0.328 |
| Pain intensity | 4.0 (3.0–5.3) | 4.0 (3.0–4.5) | 5.0 (3.0–6.0) | 0.181 | |
| After 7 days | Presence of pain | 52 (93) | 24 (92) | 28 (93) | > 0.900 |
| Pain intensity | 4.0 (3.0–5.3) | 4.0 (3.0–5.3) | 4.0 (4.0–5.3) | 0.509 | |
| After 14 days | Presence of pain | 53 (95) | 25 (96) | 28 (93) | > 0.900 |
| Pain intensity | 4.0 (3.0–6.0) | 3.0 (3.0–5.0) | 5.0 (3.0–6.5) | 0.062 | |
| After 21 days | Presence of pain | 51 (91) | 25 (96) | 26 (87) | 0.358 |
| Pain intensity | 4.0 (2.3–6.0) | 3.0 (2.0–4.0) | 6.0 (3.3–7.0) | 0.001 | |
| Eating soft food | |||||
| Baseline | Presence of pain | 25 (45) | 11 (42) | 14 (47) | > 0.900 |
| Pain intensity | 2.0 (2.0–4.0) | 2.0 (2.0–3.5) | 2.5 (2.0–5.0) | 0.440 | |
| After 7 days | Presence of pain | 28 (50) | 11 (42) | 17 (57) | 0.422 |
| Pain intensity | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 2.0 (2.0–4.0) | 0.434 | |
| After 14 days | Presence of pain | 23 (41) | 7 (27) | 16 (53) | 0.059 |
| Pain intensity | 4.0 (2.8–6.0) | 3.0 (2.5–7.0) | 4.0 (2.9–6.0) | 0.892 | |
| After 21 days | Presence of pain | 21 (38) | 7 (27) | 14 (47) | 0.170 |
| Pain intensity | 5.0 (3.0–7.0) | 3.0 (2.0–6.5) | 5.5 (3.0–7.0) | 0.327 | |
| During speech | |||||
| Baseline | Presence of pain | 9 (16) | 3 (12) | 6 (20) | 0.481 |
| Pain intensity | 4.0 (3.0–4.5) | 3.0 (2.5–4.0) | 4.0 (4.0–4.4) | 0.356 | |
| After 7 days | Presence of pain | 10 (18) | 3 (12) | 7 (23) | 0.310 |
| Pain intensity | 3.0 (2.0–4.8) | 2.0 (1.5–3.5) | 4.0 (2.0–5.0) | 0.345 | |
| After 14 days | Presence of pain | 7 (13) | 2 (8) | 5 (17) | 0.436 |
| Pain intensity | 6.0 (4.0–7.0) | 5.5 (4.8–6.3) | 6.0 (4.0–7.0) | 0.839 | |
| After 21 days | Presence of pain | 10 (18) | 3 (12) | 7 (23) | 0.310 |
| Pain intensity | 6.0 (5.0–7.0) | 5.0 (5.0–6.5) | 6.0 (5.5–7.0) | 0.728 | |
Data are presented as an absolute number (percentage of the total number of respondents in the subject group) or as a median (interquartile range, IQR)