Exploration of Drug Science

Semi-synthetic antibacterials	Mechanism of action	Reference
Ceftaroline	Binds to penicillin-binding proteins, disrupts cell wall synthesis and cross-linking, leading to weakened cell walls, bacterial lysis, and cell death.	[39]
Dalbavancin	Inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan chains, disrupting transpeptidation, which results in a weakened cell wall and bacterial lysis.	[40]
Oritavancin	Utilizes three mechanisms: i) inhibition of transglycosylation, ii) inhibition of transpeptidation, and iii) disruption of bacterial cell membrane.	[41]

Semi-synthetic antibacterials

Mechanism of action

Reference

Ceftaroline

Binds to penicillin-binding proteins, disrupts cell wall synthesis and cross-linking, leading to weakened cell walls, bacterial lysis, and cell death.

[39]

Dalbavancin

Inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan chains, disrupting transpeptidation, which results in a weakened cell wall and bacterial lysis.

[40]

Oritavancin

Utilizes three mechanisms: i) inhibition of transglycosylation, ii) inhibition of transpeptidation, and iii) disruption of bacterial cell membrane.

[41]