Effect of oral administration of ethanolic extract of M. myristica seed and selenium nanoparticle on fasting blood glucose levels in streptozotocin-induced diabetic rats
| Parameters/Days | NDR | DR + dH2O | DR + metformin | DR + 25 mg/kg b.wt of EEMS | DR + 50 mg/kg b.wt of EEMS | DR +100 mg/kg b.wt of EEMS | DR + 10 mg/kg b.wt of SeNP | DR + 20 mg/kg b.wt of SeNP |
|---|---|---|---|---|---|---|---|---|
| Day 0 | 67.20 ± 7.50 a | 63.40 ± 13.43 a | 67.60 ± 8.26 a | 66.80 ± 11.65 a | 66.80 ± 10.45 a | 66.00 ± 10.93 a | 62.40 ± 11.13 a | 64.20 ± 10.33 a |
| Day 1 | 71.20 ± 15.27 α | 418.40 ± 44.59 b | 347.40 ± 44.46 b | 426.80 ± 62.29 b | 354.80 ± 53.05 b | 440.00 ± 83.56 b | 432.00 ± 30.06 b | 458.00 ± 52.96 b |
| Day 4 | 61.60 ± 8.71 a | 256.80 ± 23.53 b | 166.80 ± 20.25 c | 233.00 ± 53.32 b, c | 75.00 ± 14.98 a | 291.00 ± 37.16 b | 263.20 ± 57.10 b | 157.60 ± 44.40 c |
| Day 7 | 50.00 ± 10.65 a | 276.00 ± 21.22 b | 141.00 ± 34.29 c | 130.60 ± 50.25 c | 51.20 ± 18.36 a | 273.80 ± 30.72 b | 153.00 ± 42.76 b, c | 194.40 ± 4.93 c |
| Day 10 | 56.20 ± 6.65 a | 266.80 ± 26.50 c | 94.60 ± 27.51 a, b | 114.60 ± 57.57 a | 61.00 ± 14.30 a | 242.60 ± 68.23 c | 115.60 ± 6.66 a, b | 94.80 ± 19.84 a, b |
| Day 13 | 60.00 ± 9.41 a | 284.80 ± 31.59 c | 79.20 ± 24.17 a | 127.60 ± 49.39 a, b | 64.80 ± 7.79 a | 227.20 ± 33.55 d | 70.80 ± 23.53 a | 80.00 ± 15.81 a |
| Day 14 | 62.40 ± 11.52 a | 267.80 ± 25.77 b | 66.40 ± 13.61 a | 62.60 ± 8.05 a | 69.20 ± 11.17 a | 194.00 ± 43.15 c | 63.20 ± 8.04 a | 70.00 ± 21.89 a |
Values are means of five replicates ± STD. Values with different superscript are significantly different (P < 0.05) from others. Statistical significance was determined using superscripts (e.g., a, b, c and d) to indicate differences among groups at a significance level of P < 0.05 (5%). NDR: non-diabetic rats; DR: diabetic rats; dH2O: distilled water; SeNPs: selenium nanoparticles; b.wt: body weight; EEMS: ethanolic extract of M. myristica seed; Day 0: FBS level pre-induction