Exploration of Drug Science

From: Behind anticancer molecules: lactoferricin dimeric peptides with fast, selective, persistent and broad-spectrum cytotoxic effect

Table 3

Cytotoxic effect of the dimeric peptides 10–13 against colon cancer cells HT-29 (cells were treated for 2 h at 37°C)

Code	Sequence	IC₅₀ (μM)		Selectivity index		Haemolysis (%)
Code	Sequence	HT-29	Fibroblasts	SI¹	SI³	Haemolysis (%)
10	(RWQWRWQWR)₂-K-Ahx	34	34	1.0	> 1.9	2
11	(Ahx-RWQWRWQWR)₂-K-Ahx	49	19	0.4	> 1.2	1
12	(RWQWRWQW-Orn)₂-K-Ahx	12	4	0.3	> 5.1	1
13	(CH₃CO-RWQWRWQWR)₂-K-Ahx	12	> 61	> 5.0	> 5.0	3

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Haemolysis (%) is reported at peptide concentration of 200 μg/mL. ${S I}^{1} = \frac{{I C}_{50 F i b r o b l a s t}}{{I C}_{50 H T - 29}}$ ; ${S I}^{3} = \frac{{I C}_{50 R B C}}{{I C}_{50 H T - 29}}$ . RBC: red blood cells; SI: selectivity index