Cytotoxic effect of the dimeric peptides in HT-29 cells treated by 2 or 24 h
Code | Sequence | IC50 (µM) | |
---|---|---|---|
2 h | 24 h | ||
26[F] | (RRWQWRFKKLG)2-K-Ahx | 12 | 26 |
2 | (Orn-RWQWRFKKLG)2-K-Ahx | 18 | 22 |
3 | (R-Orn-WQWRFKKLG)2-K-Ahx | 30 | 10 |
4 | (RRWQW-Orn-FKKLG)2-K-Ahx | 49 | 29 |
5 | (dR-Orn-WQWRFKKLG)2-K-Ahx | 20 | 23 |
6 | (dRRWQW-Orn-FKKLG)2-K-Ahx | 35 | 19 |
8 | (Biotin-Ahx-RRWQWRFKKLG)2-K-Ahx | 19 | 22 |
10 | (RWQWRWQWR)2-K-Ahx | 34 | 7 |
12 | (RWQWRWQW-Orn)2-K-Ahx | 12 | 6 |
13 | (CH3CO-RWQWRWQWR)2-K-Ahx | 12 | 13 |