Comparison between minimal and whole body PBPK prediction for Cmax
| Range | mPBPK | Whole body PBPK | ||
|---|---|---|---|---|
| Within the range # | Within the range (%) | Within the range # | Within the range (%) | |
| Mild (n = 9) | ||||
| 0.5–2 | 8 | 89 | 7 | 78 |
| 0.5–1.5 | 7 | 78 | 6 | 67 |
| 0.7–1.3 | 2 | 22 | 3 | 33 |
| > 2 | 0 | 0 | 2 | 22 |
| < 0.5 | 1 | 11 | 0 | 0 |
| AFE | 0.96 | - | 1.28 | - |
| Moderate (n = 16) | ||||
| 0.5–2 | 10 | 63 | 12 | 75 |
| 0.5–1.5 | 9 | 56 | 9 | 56 |
| 0.7–1.3 | 8 | 50 | 5 | 31 |
| > 2 | 4 | 25 | 4 | 25 |
| < 0.5 | 2 | 13 | 0 | 0 |
| AFE | 1.04 | - | 1.22 | - |
| Severe (n = 8) | ||||
| 0.5–2 | 3 | 38 | 4 | 50 |
| 0.5–1.5 | 1 | 13 | 3 | 38 |
| 0.7–1.3 | 1 | 13 | 2 | 25 |
| > 2 | 5 | 63 | 4 | 50 |
| < 0.5 | 1 | 13 | 0 | 0 |
| AFE | 1.66 | - | 1.71 | - |
n = 27 drugs. -: no data. #: number of drugs. AFE: average fold error; Cmax: maximum plasma concentration; mPBPK: minimal physiologically based pharmacokinetic; PBPK: physiologically based pharmacokinetic