Prediction statistics for AUC and Cmax by mPBPK (n = 52 drugs)
| Range | mPBPK (AUC) | mPBPK (Cmax) | ||
|---|---|---|---|---|
| Within the range # | Within the range (%) | Within the range # | Within the range (%) | |
| Mild | n = 37 | n =25 | ||
| 0.5–2 | 34 | 92 | 24 | 96 |
| 0.5–1.5 | 30 | 81 | 20 | 80 |
| 0.7–1.3 | 23 | 62 | 15 | 60 |
| > 2 | 0 | 0 | 2 | 8 |
| < 0.5 | 3 | 8 | 0 | 0 |
| AFE | 1.05 | - | 1.18 | - |
| Moderate | n = 47 | n = 38 | ||
| 0.5–2 | 44 | 94 | 34 | 89 |
| 0.5–1.5 | 41 | 87 | 26 | 68 |
| 0.7–1.3 | 29 | 62 | 20 | 53 |
| > 2 | 0 | 0 | 5 | 13 |
| < 0.5 | 3 | 6 | 0 | 0 |
| AFE | 0.95 | - | 1.21 | - |
| Severe | n = 36 | n = 30 | ||
| 0.5–2 | 32 | 89 | 23 | 77 |
| 0.5–1.5 | 28 | 78 | 16 | 53 |
| 0.7–1.3 | 19 | 53 | 11 | 37 |
| > 2 | 0 | 0 | 8 | 27 |
| < 0.5 | 3 | 8 | 0 | 0 |
| AFE | 0.90 | - | 1.42 | - |
-: no data. #: number of drugs. The number of observations in Table 4 is the total number of observations from mPBPK (Tables 2 and 3) and the additional data analysis of 25 drugs. AFE: average fold error; AUC: area under the curve; Cmax: maximum plasma concentration; mPBPK: minimal physiologically based pharmacokinetic