Changes in hepatic vascular parameters reported in experimental NAFLD
| Authors/Year | Study type | Liver disease characteristics | Major findings |
|---|---|---|---|
| Wada et al. (1974) [20] | Male Donryu rats, choline-deficient vs. control diet(n = 12 vs. 27) | Steatosis, steatosis with fibrosis, or cirrhosis after 8 to 38 weeks of intervention | Sinusoidal narrowing, decreased venous flow (60%), and increased portal pressure present in steatosis alone |
| Seifalian et al. (1999) [21] | New Zealand white rabbits, high cholesterol vs. control diet for 4, 8, and 12 weeks(n = 6 vs. 18) | Steatosis | Total hepatic blood flow (137 ± 6 mL/min) reduced to 99 ± 5 mL/min (P < 0.002), and 63 ± 5 mL/min (P < 0.002) in steatotic livers after 8 and 12 weeks, respectively |
| Sun et al. (2003) [22] | Male Zucker obese vs. lean rats (25 to 30 weeks of age)(n = 7 vs.7) | Massive steatosis, no cirrhosis | Reduced total hepatic blood flow (35%) and portal venous flow (38%) in steatosis |
| Francque et al. (2010) [23] | Male Wistar rats, methionine-choline-deficient vs. control diet for 4 weeks(n = 12 vs. 12) | Steatosis with nearly absent inflammation and no fibrosis | Vasodilator response to phenylephrine blunted in steatotic livers and portal venous pressure increased from 2.8 ± 0.5 mmHg to 9.0 ± 0.7 mmHg (P < 0.001) |
| Pasarin et al. (2012) [24] | Male Wistar Kyoto rats, cafeteria vs. control diet for 1 months(n = 7 vs. 7) | Steatosis without inflammation or fibrosis | Vasodilator response to acetylcholine blunted in steatotic livers and IHVR increased 2.2-fold |
| Garcia-Lezana et al. (2018) [25] | Male Sprague-Dawley rats, high-glucose/fructose, high-fat vs. control diet (n = 6 vs. 6) for 8 weeks (experiment 1) used for heterologous vs. autologous fecal microbiota transplantation (experiment 2)(n = 10 to 14) | Steatohepatitis with mild or absent fibrosis | Dietary intervention increased PVP from 8.75 ± 0.52 mmHg to 10.71 ± 0.44 mmHg (P = 0.018), but corrected by fecal microbiota transplantation derived from rats on control diet |
| Van der Graaff et al. (2018) [26] | Male Wistar rats, methionine-choline-deficient vs. control diet for 4 weeks (experiment 1, n = 12 vs. 12) validated in experiment 2(n = 12 vs. 12) | Severe steatosis with mild lobular inflammation and absent fibrosis | Vasoconstriction less responsive to blunting by indomethacin in steatotic livers and transhepatic pressure gradient increased to 9.5 ± 0.5 mmHg from 2.3 ± 0.5 mmHg in controls (P < 0.001) |