Exploration of Medicine

Table 2. A summary of the functions of circRNAs in ischemic stroke

circRNAs	Regulation	Regulation targets and pathways	Effects	Refs
circSCMH1	Down	circSCMH1/MeCP2 axis	Enhance neuronal plasticity, inhibit glial activation and peripheral immune cell infiltration	[87]
circOGDH	Up	circOGDH/miR-5112/COL4A4 axis	Enhance COL4A4 expression to elevate neuron damage	[89]
circHECTD1	Up	circHECTD1/miR-142/TIPARP axis	Promote astrocyte activation	[46]
circUCK2	Down	circUCK2/miR-125b-5p/GDF11 axis	Improve the cell survival rate and ameliorate neuronal injury	[88]
circSHOC2	Up	circSHOC2/miR-7670-3p/SIRT1 axis	Inhibit neuronal apoptosis via promoting autophagy and inhibit neuronal death	[75]
circCDC14A	Up	-	Promote astrocytes activation	[90]
circTLK1	Up	circTLK1/miR-335-3p/TIPARP axis	Aggravate neuronal injury and neurological deficit.	[91]
circDLGAP4	Down	circDLGAP4/miR-143/HECTD1 axis	Inhibite EndoMT and attenuate BBB damage	[92]

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circOGDH: circular RNA OGDH; COL4A4: Gallus collagen, type IV, alpha IV; circHECTD1: circular RNA HECTD1; circCDC14A: circular RNA CDC14A; circTLK1: circular RNA TLK1; circDLGAP4: circular RNA DLGAP4; EndoMT: endothelial-to-mesenchymal transition

Declarations

Author contributions

YH and LG: Investigation, Writing—original draft, Writing—review & editing. BH: Conceptualization, Validation, Writing—review & editing. HY: Conceptualization, Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by the Science and Technology innovation 2030-Major Project of the Ministry of Science and Technology of China [2021ZD0202904/2021ZD0202900], the National Natural Science Foundation of Distinguished Young Scholars [82025033], the National Natural Science Foundation of China [82230115, 82003733], the Natural Science Foundation of Jiangsu Province [BK20200358], the Fundamental Research Funds for the Central Universities [2242021R40023], the Jiangsu Provincial Doctors of Entrepreneurship and Innovation Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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