From:  Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target

List of information on MCTs inhibitors

MCTs inhibitorsSite of actionShortcomingsReferences
LonidamineMCT1, MCT2, MCT4Less effective[102]
QuercetinMCT1Does not affect cell migration[103, 106]
SimvastatinMCT4Does not affect cell migration[104, 106]
DIDSMCT FamilyDoes not affect cell migration[105, 106]
AR-C155858MCT1 (Ki = 2.3 nM), MCT2Novel inhibitors to be studied[107]
AZD3965MCT1 (Ki = 1.6 nM), MCT2 (Ki = 20 nM)Novel inhibitor in Phase I clinical trials[16, 111, 113]
BAY-8002MCT1, MCT2 (MCT1 is 5 times more selective than MCT2)Novel inhibitor, not in clinical trials[114]
BindaritMCT4Newly identified inhibitors to be studied[115]
VB124MCT4Novel inhibitors to be studied[117]
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DIDS: 4,4’-diisothiocyanatostilbene-2,2’-disulfonic acid