Exploration of Medicine

Drug mechanisms and classification	Class-I (topoisomerase poisons)	Class-II (topoisomerase inhibitors)
Mechanism of drug action	These drugs act as intermediaries in the catalytic cycle of the enzyme, blocking the creation of a covalent topoisomerase-DNA network.	These medications interfere with the enzyme’s catalytic action without trapping the covalent compound.
Nomenclature and classification of drug types	Class-I medications are sometimes referred to as “topoisomerase poisons” since they convert the enzyme into a strong cellular toxin.	Class-II drugs are assigned as “topoisomerase inhibitors.”
Varieties of topoisomerase medications	Class-I medications contain acridines, alkaloids, anthracyclines, ellipticines, epipodophyllotoxins, actinomycin, quinolones, and isoflavonoids.	Class-II medications are fostriecin analogues and coumarin antibiotics.

Drug mechanisms and classification

Class-I (topoisomerase poisons)

Class-II (topoisomerase inhibitors)

Mechanism of drug action

These drugs act as intermediaries in the catalytic cycle of the enzyme, blocking the creation of a covalent topoisomerase-DNA network.

These medications interfere with the enzyme’s catalytic action without trapping the covalent compound.

Nomenclature and classification of drug types

Class-I medications are sometimes referred to as “topoisomerase poisons” since they convert the enzyme into a strong cellular toxin.

Class-II drugs are assigned as “topoisomerase inhibitors.”

Varieties of topoisomerase medications

Class-I medications contain acridines, alkaloids, anthracyclines, ellipticines, epipodophyllotoxins, actinomycin, quinolones, and isoflavonoids.

Class-II medications are fostriecin analogues and coumarin antibiotics.