Exploration of Medicine

Disease model	Treatment	Comparator	Results	Ref.
C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line	CBD (0, 12.5, or 25 mg/kg i.p.) single dose	Phosphate-buffered saline	Maximal apoptosis after 25 mg/kg; 12.5 mg/kg increased apoptosis but did not reach level of significance. CBD-induced apoptosis was mediated through CB2	[89]
C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line	THC (0, 1, 3, or 5 mg/kg i.p.) single dose	Phosphate-buffered saline	THC caused a dose-dependent decrease in the viable tumour-cell number in the peritoneal cavity. With 5 mg/kg, a signif. proportion (77.3%) of the tumor cells showed apoptosis	[90]

Disease model

Treatment

Comparator

Results

Ref.

C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line

CBD (0, 12.5, or 25 mg/kg i.p.) single dose

Phosphate-buffered saline

Maximal apoptosis after 25 mg/kg; 12.5 mg/kg increased apoptosis but did not reach level of significance. CBD-induced apoptosis was mediated through CB2

[89]

C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line

THC (0, 1, 3, or 5 mg/kg i.p.) single dose

Phosphate-buffered saline

THC caused a dose-dependent decrease in the viable tumour-cell number in the peritoneal cavity. With 5 mg/kg, a signif. proportion (77.3%) of the tumor cells showed apoptosis

[90]