Studies of the composition of granulomas and interstitial lung tissue in the BCG-induced granulomatous model
| Parameter | Reference | |||||
|---|---|---|---|---|---|---|
| [15] | [16] | [36] | [73] | [77] | [95] | |
| Time after BCG infection (days) | 3, 30 | 14–28 | 3–180 | 3–180 | 30–180 | 7–28 |
| Lung granulomas | ||||||
| Numerical density | √ | √ | √ | |||
| Diameter | √ | √ | √ | |||
| Сollagen fibers | √ | √ | √ | |||
| TNF-α | √ | √ | ||||
| Caspase 3 | √ | |||||
| TRAIL | √ | |||||
| Macrophages | √ | √ | √ | |||
| Fibroblasts | √ | √ | √ | |||
| Epithelioid cell | √ | √ | ||||
| Lymphocyte | √ | √ | ||||
| Lung interstitium | ||||||
| Collagen fibers | √ | √ | √ | |||
| sGAG | √ | |||||
| Protein | √ | |||||
| Uronic acids | √ | |||||
| Galactose | √ | |||||
| Hydroxyproline | √ | √ | √ | |||
| TNF-α | √ | |||||
| TGF-β | √ | |||||
| Macrophages | √ | |||||
| Fibroblasts | √ | |||||
Blank cells represent no description. TRAIL: TNF-related apoptosis-inducing ligand; sGAG: sulfated GAG; TGF-β: transforming growth factor-β; √: included in the study