Exploration of Medicine

Aspect	Outcomes	Findings
Epidemiology	Reduced levels of oestrogens on schizophrenia incidence	Second peak of incidence at menopause in women [25, 73]
Psychopathological symptoms	Symptom severity and clinical stability	Menopause correlates with 1) increased severity of psychosis [74] and 2) antipsychotic resistance [74–82]
Physical health	Breast cancer—incidence and mortality	Increased incidence attributed to drug-induced hyperprolactinemia. Increased mortality attributed to low rates of cancer screening and medical neglect [83, 84]
Medical co-morbidity	Osteoporosis and type 2 diabetes attributed to antipsychotics [82]

Aspect

Outcomes

Findings

Epidemiology

Reduced levels of oestrogens on schizophrenia incidence

Second peak of incidence at menopause in women [25, 73]

Psychopathological symptoms

Symptom severity and clinical stability

Menopause correlates with 1) increased severity of psychosis [74] and 2) antipsychotic resistance [74–82]

Physical health

Breast cancer—incidence and mortality

Increased incidence attributed to drug-induced hyperprolactinemia. Increased mortality attributed to low rates of cancer screening and medical neglect [83, 84]

Medical co-morbidity

Osteoporosis and type 2 diabetes attributed to antipsychotics [82]