Studies reporting changes in the human ocular surface microbiome of DED state subtypes compared to healthy controls
| First author | Year | Study type | DED type | Patients (N) | Significant alpha diversity change | Increased bacterial abundance or detection | Decreased bacterial abundance or detection |
|---|---|---|---|---|---|---|---|
| Andersson [22] | 2021 | Case-control | ADDE | 18 | Reduced | NR | 52 genera less abundant |
| Zhang [32] | 2021 | Case-control | NR | 34 | Not significant | Pseudomonas Methylobacterium Bacteroides | Actinobacteria |
| Zilliox [33] | 2020 | Case-control | NR | 8 | Reduced | Corynebacterium Staphylococcus | NR |
| Li [34] | 2019 | Case-control | Combined | 35 | Reduced | Bacteroidia Bacteroidetes | Pseudomonas Pseudomonas plecoglossicida Pseudomonadaceae Gammaproteobacteria Proteobacteria |
| Dong [21] | 2019 | Case-control | Evaporative | 47 | Not significant | Bacillales Proteobacteria Bacilli Staphylococcus Staphylococcaceae Firmicutes Staphlococcus epidermidis Alphaproteobacteria Gammaproteobacteria Sphingomonas Sphingomonadaceae Sphingomonadales Sphingomonas melonis | Actinomycetales Actinobacteria Corynebacteriaceae Corynebacterium |
| Jiang [26] | 2018 | Case-control | EDE | 41 | Increased | Bacillus Micrococcus luteus Staphylococcus epidermidis Staphylococcus Microbacteriaceae | NR |
| Graham [25] | 2007 | Case-control | NR | 12 | NR | Bacillus Propionbacterium acnes Klebsiella oxytoca | Erwinia |
Studies restricted to those employing RNA or DNA sequencing in lieu of culture only. EDE: evaporative dry eye; NR: not recorded