Detailed examination of the relationship between CD34+CD133+ (log-transformed) and the risk of AD/dementia risk
| CD34+CD133+ cells plus covariates | AD | All-cause dementia | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Model 1: no covariates | 0.57 (0.40, 0.81)n = 1,617 | 0.002* | 0.57 (0.42, 0.77)n = 1,640 | 0.003* |
| Model 2: age, sex, years of education | 0.64 (0.45, 0.93)n = 1,617 | 0.02* | 0.64 (0.47, 0.87)n = 1,640 | 0.005* |
| Model 3: Model 2 + APOE ɛ4 + vascular diseases | 0.64 (0.44, 0.94)n = 1,340 | 0.02* | 0.63 (0.45, 0.87)n = 1,362 | 0.006* |
| Model 3 after stratification | ||||
| No vascular diseasesa | 1.23 (0.15, 10.18)n = 256 | 0.85 | 1.12 (0.19, 6.56)n = 257 | 0.90 |
| Peripheral vascular diseasesb only | 0.62 (0.40, 0.94)n = 832 | 0.02* | 0.61 (0.43, 0.88)n = 850 | 0.008* |
| Cerebrovascular diseasesc only | 0.58 (0.35, 0.96)n = 628 | 0.03* | 0.53 (0.35, 0.81)n = 641 | 0.003* |
Cox proportional hazards regression models were used to study the relationship between log-transformed CD34+CD133+ cell frequency (%) and the risk of AD or all-cause dementia after adjusting for the covariates. HR with 95% CI with P values is shown. Model 1: simple association without confounders; Model 2: adjusting for age, sex, and education; Model 3: Model 2 + APOE ɛ4 + vascular diseases. a Model 3 after the stratification as no vascular diseases for those with no CHD, no HTN, no stroke, no silent infarct, no CMB, and low level of WMHI; b Model 3 after the stratification as peripheral vascular diseases for those with CHD or HTN; c Model 3 after the stratification as cerebrovascular diseases for those with stroke, silent infarct, CMB, or high level of WMHI; * P value significant < 0.05