Interactions between SNPs of KIRREL3 or EXOC6B and CD34+CD133+ on AD risk in FHS
| Gene locus | Chr:Pos (GRCh37) | Major allele | Minor allele | dbSNP ID | Function | MAF | AD risk | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Main effect of SNPa | Interaction effect (GEEPACK)(SNP with CD34+CD133+)b | Interaction effect (Cox)(SNP with CD34+CD133+)c | ||||||||||
| OR(95% CI) | P value | OR(95% CI) | P value | HR(95% CI) | P value | |||||||
| KIRREL3 | chr11:126434673 | T | G | rs4144611 | Intron | 0.39 | 1.12 (–0.15, 0.37) | 0.40 | 5.52 (3.18, 9.56) | 1.3 × 10–8* | 2.71 (1.67, 4.40) | 5.61 × 10–7* |
| KIRREL3 | chr11:126438111 | C | T | rs580382 | Intron | 0.35 | 1.07 (–0.20, 0.33) | 0.62 | 5.00 (2.98, 8.39) | 1.3 × 10–8* | 3.69 (2.21, 6.14) | 5.28 × 10–5* |
| EXOC6B | chr2:72754104 | C | G | rs61619102 | Intron | 0.16 | 0.96 (–0.39, 0.31) | 0.84 | 4.66 (2.79, 7.80) | 4.2 × 10–8* | 4.69 (2.05, 10.75) | 2.59 × 10–4* |
a Using logistic regression model, AD was associated with different SNPs after adjusting for age, sex, years of education, APOE ɛ4, and PCs; b using GWAS GEEPACK (logistic regression utilizing generalized estimating equations), AD was associated with different SNPs, (CD34+CD133+) and SNP:(CD34+CD133+) after adjusting for age, sex, years of education and PCs; c Using Cox proportional hazards regression model, AD incidence was associated with SNP, (CD34+CD133+), the interaction between SNP and (CD34+CD133+) after adjusting for age, sex, years of education, APOE ɛ4, PCs, and vascular diseases; * P value significant < 0.05; Chr: chromosome; Pos: position