The association between circulating CD34+CD133+ cells and the risk of AD in the context of genetic background
| rs4144611 (KIRREL3) | rs580382 (KIRREL3) | rs61619102 (EXOC6B) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | CD34+CD133+ cutoffs | HR(95% CI) | P value | Genotype | CD34+CD133+ cutoffs | HR(95% CI) | P value | Genotype | CD34+CD133+ cutoffs | HR(95% CI) | P value |
| TT | 25% | 0.18 (0.07–0.46) | 3.3 × 10-4* | CC | 25% | 0.21 (0.09–0.47) | 1.7 × 10-4* | CC | 25% | 0.48 (0.26–0.88) | 0.02* |
| 50% | 0.11 (0.03–0.42) | 0.001* | 50% | 0.16 (0.05–0.47) | 9.6 × 10-4* | 50% | 0.38 (0.19–0.74) | 0.005* | |||
| 75% | N/A (zero AD) | 0.006a* | 75% | N/A (zero AD) | 0.002a* | 75% | 0.25 (0.08–0.81) | 0.02* | |||
| GG + TG | 25% | 1.02 (0.46–2.25) | 0.96 | TT + CT | 25% | 1.80 (0.68–4.82) | 0.24 | GG + GC | 25% | 2.22 (0.39–12.64) | 0.37 |
| 50% | 1.54 (0.76–3.15) | 0.23 | 50% | 2.44 (1.07–5.56) | 0.03* | 50% | 12.38 (2.00–76.65) | 0.007* | |||
| 75% | 1.39 (0.64–3.05) | 0.41 | 75% | 1.80 (0.80–4.07) | 0.16 | 75% | 5.68 (1.65–19.61) | 0.006* | |||
Participants were first stratified into KIRREL3 rs4144611 TT vs. GG + TG; rs580382 CC vs. TT + CT as well as in EXOC6B rs61619102 CC vs. GG + GC genotype groups. Using Cox proportional hazards regression model, AD incidence was associated with (CD34+CD133+ cutoffs: 25%, 50%, and 75%) after adjusting for age, sex, years of education, APOE ɛ4, and PCs for each genotype group. a When CD34+CD133+ is higher than the 75% percentile, there are no AD cases among these genotypes, KIRREL3 rs4144611 TT, KIRREL3 rs580382 CC, and EXOC6B; * P value significant < 0.05