From:  Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

Number of animals (%) with histological cutaneous lesions in all experimental groups

Histological cutaneous lesionsG1 WT waterG2 HPV waterG3 WT 0.013 g/mLG4 HPV 0.006 g/mLG5 HPV 0.008 g/mLG6 HPV 0.013 g/mL
Ear pavilion lesions
Dysplasia0(0%)15(100%)0(0%)5(100%)4(80%)4(80%)
Papilloma0(0%)3(50%)0(0%)2(40%)0(0%)1(20%)
Sebaceous hyperplasia0(0%)4(80%)0(0%)3(60%)4(80%)1(20%)
Inflammatory infiltrate0(0%)15(100%)0(0%)25(100%)5(100%)5(100%)
Congestion0(0%)15(100%)0(0%)20(0%)0(0%)1(20%)
Hyperplasia
        Simple        Focal0(0%)0(0%)0(0%)0(0%)0(0%)1(20%)
        Diffuse0(0%)0(0%)0(0%)0(0%)1(20%)(0%)
        Papillary        Focal0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
        Diffuse0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
        Papillomatosis        Focal0(0%)2(40%)0(0%)3(60%)4(80%)2(40%)
        Diffuse0(0%)2(40%)0(0%)1(20%)0(0%)0(0%)
Carcinoma
        Carcinoma in situ0(0%)1(20%)0(0%)0(0%)0(0%)0(0%)
        Small invasive carcinoma0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
        Invasive carcinoma0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Chest skin lesions
Dysplasia0(0%)15(100%)0(0%)5(100%)4(80%)4(80%)
Sebaceous hyperplasia0(0%)15(100%)0(0%)25(100%)4(80%)5(100%)
Inflammatory infiltrate0(0%)4(80%)0(0%)4(80%)3(50%)3(50%)
SimpleSimple0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Diffuse0(0%)0(0%)0(0%)0(0%)0(0%)1(20%)
PapillaryDiffuse0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Focal0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
PapillomatosisDiffuse0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Focal0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
PapilomaInverted papiloma0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Exophytic papiloma0(0%)2(40%)0(0%)1(20%)1(20%)1(20%)
CarcinomaCarcinoma in situ0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Small invasive carcinoma0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Invasive carcinoma0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
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1 Significantly different from the G2 (P < 0.05). 2 Significantly different from the G6 (P < 0.05). G1 are wild-type (WT) mice that drink water; G2 are mice with human papillomavirus (HPV) that drank water; G3 are WT that drank daily an aqueous extract of Aloysia citrodora at a concentration of 0.013 g/mL; G4 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.006 g/mL; G5 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.008 g/mL; G6 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.013 g/mL