From:  Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

Number of animals (%) with histological lesions in the lungs, liver, spleen, and kidney in all experimental groups

Histological organs lesionsG1 WT waterG2 HPV waterG3 WT 0.013 g/mLG4 HPV 0.006 g/mLG5 HPV 0.008 g/mLG6 HPV 0.013 g/mL
Lungs
Mononucleated inflammation intensity0(0%)3(60%)0(0%)1(20%)1(20%)1(20%)
Atelectasis0(0%)15(100%)2(40%)1(20%)1(20%)4(80%)
Congestion3(60%)5(100%)0(0%)2(40%)0(0%)3(60%)
Hyperaemia4(80%)0(0%)0(0%)0(0%)0(0%)0(0%)
Liver
Hydropic degeneration0(0%)1(20%)0(0%)0(0%)2(40%)0(0%)
Inflammatory infiltratePeriportal0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Centrilobular0(0%)0(0%)0(0%)0(0%)0(0%)0(0%)
Midzonal0(0%)5(100%)3(60%)3(60%)3(60%)1(20%)
Congestion5(100%)5(100%)1(20%)2(40%)3(60%)5(100%)
Spleen
Diffuse white pulp: hyperplasia0(0%)0(0%)2(40%)1(20%)4(80%)1(20%)
Expansion of the splenic red pulp: congestion0(0%)4(80%)0(0%)0(0%)0(0%)0(0%)
Kidney
Inflammatory infiltrate1(20%)5(100%)0(0%)3(60%)3(60%)3(60%)
Hydronephrosis1(20%)4(80%)1(20%)1(20%)1(20%)0(0%)
Congestion5(100%)5(100%)5(100%)3(60%)5(100%)5(100%)
Hyperaemia1(20%)3(60%)0(0%)0(0%)1(20%)0(0%)
Vascular ectasia0(0%)1(20%)0(0%)0(0%)0(0%)0(0%)
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1 Significantly different from the G2 (P < 0.05). G1 are wild-type (WT) mice that drink water; G2 are mice with human papillomavirus (HPV) that drank water; G3 are WT that drank daily an aqueous extract of Aloysia citrodora at a concentration of 0.013 g/mL; G4 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.006 g/mL; G5 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.008 g/mL; G6 are mice with HPV that drank daily an aqueous extract of A. citrodora at a concentration of 0.013 g/mL