TP53 exon 5 frequency of known variants in Moroccan prostate cancer patients and their corresponding effects according to NCBI 1000 Genomes Browser and Human Genome Variation Society (HGVS) nomenclature
| Effect | Variant ID | CDS change | Genome location | Protein change | Frequency, N = 48 |
|---|---|---|---|---|---|
| Insertion | rs786202525 | c.532_533insCCC | Chr17:7675079 | p.Pro177_His178insPro | 1 (2%) |
| Missense | rs1057519977 | c.423C>G | Chr17:7675189 | p.Cys141Trp | 9 (19%) |
| Missense | rs1131691037 | c.392A>T | Chr17:7675220 | p.Asn131Ile | 5 (10%) |
| Missense | rs138729528 | c.523C>G | Chr17:7675089 | p.Arg175Gly | 5 (10%) |
| Missense | rs1555526335 | c.377A>G | Chr17:7675235 | p.Tyr126Cys | 4 (8%) |
| Missense | rs758781593 | c.408A>C | Chr17:7675204 | p.Gln136His | 4 (8%) |
| Missense | rs1555526226 | c.439G>A | Chr17:7675173 | p.Val147Ile | 1 (2%) |
| Missense | rs28934875 | c.412G>C | Chr17:7675200 | p.Ala138Pro | 1 (2%) |
| Missense | rs587782596 | c.541C>A | Chr17:7675071 | p.Arg181Ser | 1 (2%) |
| Missense | rs730881999 | c.380C>G | Chr17:7675232 | p.Ser127Cys | 1 (2%) |
| Missense | rs786203071 | c.431A>C | Chr17:7675181 | p.Gln144Pro | 1 (2%) |
| NA | rs1321881901 | c.559+31G>A | Chr17:7675022 | NA | 26 (54%) |
| NA | rs1032547645 | c.559+22G>A | Chr17:7675031 | NA | 3 (6.25%) |
| NA | rs1221388024 | c.376-4A>T | Chr17:7675240 | NA | 1 (2%) |
| NA | rs1466952182 | c.376-51C>T | Chr17:7675287 | NA | 1 (2%) |
| NA | rs775915220 | c.559+8G>A | Chr17:7675045 | NA | 1 (2%) |
| NA | rs786202799 | c.376-2A>G | Chr17:7675238 | NA | 1 (2%) |
| Nonsene | rs757274881 | c.430C>T | Chr17:7675182 | p.Gln144Ter | 1 (2%) |
| Synonymous | rs786203928 | c.433C>T | Chr17:7675179 | p.Leu145= | 2 (4%) |
| Synonymous | rs1131691034 | c.492G>A | Chr17:7675120 | p.Lys164= | 1 (2%) |
| Synonymous | rs761222871 | c.468C>T | Chr17:7675144 | p.Arg156= | 1 (2%) |
| Synonymous | rs876659481 | c.456G>A | Chr17:7675156 | p.Pro152= | 1 (2%) |
CDS: coding DNA sequences