Prediction of the effects of novel missense variants on the TP53 protein by SIFT and PolyPhen 2.0 tools
| CDS | Protein change | SIFT | Polyphen | ||
|---|---|---|---|---|---|
| Score | Effect | Score | Effect | ||
| c.502C>A | p.His168Asn | 0.02 | Affect protein function | 0.995 | Probably damaging |
| c.382C>T | p.Pro128Ser | 0.13 | Tolerated | 0.967 | Probably damaging |
| c.398T>G | p.Met133Arg | 0 | Affect protein function | 0.021 | Benign |
| c.413C>G | p.Ala138Gly | 0 | Affect protein function | 1 | Probably damaging |
| c.457C>G | p.Pro153Ala | 0.11 | Tolerated | 0.001 | Benign |
| c.550G>C | p.Asp184His | 0.03 | Affect protein function | 0.965 | Probably damaging |
| c.376_377delinsCT | p.Tyr126Arg | 0 | Affect protein function | 1 | Probably damaging |
| c.427G>C | p.Val143Leu | 0.09 | Tolerated | 0.466 | Possibly damaging |
| c.428_429delinsG | p.Val143Ala | 0 | Affect protein function | 1 | Probably damaging |
| c.428T>A | p.Val143Glu | 0 | Affect protein function | 1 | Probably damaging |
| c.431_432delinsGG | p.Gln144Pro | 0.04 | Affect protein function | 1 | Probably damaging |
| c.432_433delinsCA | p.Gln144His | 0.03 | Affect protein function | 0.999 | Probably damaging |
| c.443A>T | p.Asp148Val | 0.25 | Tolerated | 0.001 | Benign |
| c.454C>A | p.Pro152Thr | 0 | Affect protein function | 0.996 | Probably damaging |
| c.461_462delinsAT | p.Gly154Asp | 0.01 | Affect protein function | 1 | Probably damaging |
| c.476C>A | p.Ala159Asp | 0 | Affect protein function | 0.992 | Probably damaging |
| c.490A>C | p.Lys164Gln | 0 | Affect protein function | 0.998 | Probably damaging |
| c.496T>G | p.Ser166Ala | 0.44 | Tolerated | 0768 | Possibly damaging |
CDS: coding DNA sequences