Exploration of Medicine

From: The casual association between mTOR-related proteins and rheumatoid arthritis: Mendelian randomization in European populations

Table 1

The results of replication MR analysis

Outcome	Exposure	SNP	IVW			MR-Egger			WM
Outcome	Exposure	SNP	OR	95%CI	p	OR	95%CI	p	OR	95%CI	p
GCST90038685	AKT	21	1.006	(0.943, 1.072)	0.866	1.051	(0.906, 1.221)	0.519	1.027	(0.947, 1.114)	0.524
	ATF6	34	0.831	(0.682, 1.014)	0.068	0.54	(0.294, 0.992)	0.057	1.048	(0.973, 1.129)	0.213
	ATG7	18	1.044	(0.953, 1.144)	0.353	0.923	(0.762, 1.118)	0.425	1.037	(0.925, 1.164)	0.533
	BECN1	26	1.033	(0.966, 1.105)	0.346	0.972	(0.825, 1.145)	0.737	1.051	(0.958, 1.152)	0.29
	EIF4A3	13	1.059	(0.996, 1.126)	0.068	1.024	(0.911, 1.150)	0.705	1.031	(0.955, 1.112)	0.439
	EIF4B	26	1.013	(0.958, 1.071)	0.65	1.082	(0.956, 1.225)	0.223	1.000	(0.919, 1.089)	0.994
	EIF4E2	24	0.994	(0.943, 1.047)	0.809	1.031	(0.929, 1.145)	0.570	1.012	(0.937, 1.094)	0.762
	EIF4EBP2	28	0.993	(0.918, 1.074)	0.861	1.064	(0.863, 1.312)	0.566	0.959	(0.866, 1.064)	0.433
	EIF4G3	21	1.009	(0.916, 1.112)	0.852	0.953	(0.755, 1.204)	0.694	0.982	(0.873, 1.105)	0.768
	HIF1A	24	0.999	(0.933, 1.070)	0.969	0.963	(0.833, 1.112)	0.612	1.028	(0.933, 1.132)	0.579
	ULK3	19	1.006	(0.917, 1.103)	0.899	1.052	(0.820, 1.350)	0.697	1.001	(0.905, 1.1.7)	0.986
	LST1	24	0.829	(0.614, 1.120)	0.222	0.870	(0.405, 1.868)	0.724	0.976	(0.895, 1.064)	0.585
	PKC-A	20	0.989	(0.926, 1.057)	0.750	0.988	(0.853, 1.143)	0.870	0.984	(0.898, 1.079)	0.735
	RPS6KA	28	1.048	(0.956, 1.150)	0.315	0.930	(0.797, 1.085)	0.369	1.011	(0.941, 1.087)	0.763

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CI: confidence interval; IVW: inverse variance weighted; MR: Mendelian randomization; OR: odds ratio; SNP: single nucleotide polymorphism; WM: weighted median