Summary of the discussed metastatic processes of breast cancer affected by various transcription factors
| Transcription factor | Metastatic process affected | ||||
|---|---|---|---|---|---|
| Angiogenesis/Vascularization | EMT/MET | Migration | Invasion | Cell cycle/Apoptosis | |
| E2F | √ | √ | √ | ||
| HIF | √ | √ | √ | ||
| EMT master regulators | √ | √ | √ | √ | |
| SOX | √ | √ | √ | √ | |
| ETS | √ | √ | √ | √ | √ |
| YY1 | √ | ||||
| FoxM1 | √ | √ | √ | ||
| Bach1 | √ | √ | √ | ||
| SIX | √ | √ | |||
| RUNX | √ | ||||
| MYC | √ | √ | |||
| KLFs | √ | √ | √ | √ | |
| c-Jun | √ | √ | |||
EMT: epithelial-mesenchymal transition; MET: mesenchymal-epithelial transition; HIF: hypoxia-inducible factor; SOX: sex determining region Y-related high-mobility group box; ETS: E26 transformation-specific; YY1: Yin Yang 1; FoxM1: forkhead box M1; Bach1: BTB domain and CNC homology 1; SIX: sineoculis homeobox homolog; MYC: myelocytomatosis; KLFs: Kruppel-like factors; RUNX: runt-related transcription factor