From:  Metabolic dysfunction-associated steatotic liver disease (MASLD): a systemic disease with a variable natural history and challenging management

CMRFs associated with MASLD†

Metabolic factorsReference value
Waist circumference≥ 102/83 cm in Caucasians or ≥ 90/80 cm in Asian
Blood pressure≥ 130/85 mmHg or drug treatment
Plasma triglycerides≥ 150 mg/dL or drug treatment
Plasma HDL≤ 40 mg/dL for men and ≤ 50 mg/dL for women or drug treatment
Fasting serum glucose≥ 100 mg/dL or 2-hours post-load glucose levels ≥ 140 mg/dL or HbA1c ≥ 5.7% or type 2 diabetes mellitus or drug treatment
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† Liver steatosis plus at least one out of 5 CMRFs for diagnosis of MASLD. CMRFs: cardio-metabolic risk factors; MASLD: metabolic dysfunction-associated steatotic liver disease; HDL: high-density lipoproteins