From:  Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies

Main non-invasive tests for the screening of silent CAD

TestTypeAdvantagesDisadvantages
Exercise stress testFunctionalLow cost
Physiologic stress
Low sensitivity
Stress echocardiographyFunctionalLow cost
Pharmacological/physiological stress
High specificity
Difficult in some patients
False negative if single vessel disease
Radionuclide imagingFunctionalHigh sensitivityRadiation
False positive
Coronary artery calciumAnatomicNon-invasiveRadiation
No stenosis evaluation
Coronary computed tomography angiographyAnatomicHigh negative predictive valueNo function evaluation
Magnetic resonance imagingAnatomic/functionalExpensivePreliminary studies