Adherence to pharmacotherapy is impacted by five categories of factors
| Sociodemographic | Health team/system | Therapy-related | Condition-related | Patient-related |
|---|---|---|---|---|
| Health literacy | Access to and cost of care including co-pays | Adverse effects | Dementia | Alternative therapies |
| Housing status | Clinician burnout | Complex regimens | Drug/alcohol abuse | Deny diagnosis |
| Income | Communication | Refill consolidation | Major disability | Fear adverse effects |
| Minority status | Fail to detect clues | Refill frequency | Mental/behavioral health | Follow-up frequency |
| Social support | Financial incentives | Time to benefit | Multiple chronic conditions | Forget |
| Transportation | Knowledge/QI infrastructure | Treatment changes | Quality of life | Future discounting |
| War/disasters | Patient centeredness | Treatment duration | Symptom severity | Knowledge/understanding |
| Young, very old | Patient-clinician relationship | Treatment failure | Perception of illness severity/impact | |
| Team-based care | Perception of treatment efficacy |
QI: quality improvement