Comparison between the differential genes related with axonal transport and autophagy across the three stages analyzed (Younger, Elder, and MCI Groups)
| Functionality | Younger | Elder | MCI |
|---|---|---|---|
| RAS-associated binding proteins (RABs) | RAB2B, RAB18, RABGAP1L, RAB40B, RAB39A, RAB33A | RAB3C, RAB4A, RAB3GAP1, RAB8B, RAB11FIP2, RAB14, RAB26 | RAB3GAP1, RAB3IP, RAB3I, RAB4B, RAB6A, RAB11FIP5, RAB27A, RAB27B, RAB31, RAB34 |
| Kinesin motor proteins (anterograde transport) | KIF1C, KIF9 | KIF1A, KIF15, KIF21B | KIF2A, KIF3C, KIF5B, KIF22 |
| Dynein motor proteins (retrograde transport) | DYNC1I2 | DYNC1LI1, DYNCC1I1 | |
| Autophagy-related cysteine peptidases (ATGs) | ATG2B, ATG4C, ATG13 | ATG3, ATG10 |