Association of VDR genotype frequencies in PCa and control participants
| SNPs | Genotypes/Alleles | Cancer cases N (%) | Controls N (%) | p-value (χ2) | OR (95% CI) |
|---|---|---|---|---|---|
| rs1544410 BsmI | BB | 16 (16%) | 30 (30%) | 0.927 | 1 (Reference)OR = 0.556; p = 0.446 (95% CI: 0.122–2.54)OR = 0.952; p = 0.947 (95% CI: 0.226–4.01) |
| Bb | 38 (38%) | 28 (28%) | |||
| bb | 46 (46%) | 42 (42%) | |||
| B | 35% | 44% | |||
| b | 65% | 56% | |||
| rs7975232 ApaI | AA | 42 (42%) | 41 (41%) | 0.045* | 1 (Reference)OR = 1.67; p = 0.3 (95% CI: 0.632–4.39)OR = 5.33; p = 0.024 (95% CI: 1.16–24.6) |
| Aa | 44 (44%) | 33 (33%) | |||
| aa | 14 (14%) | 26 (26%) | |||
| A | 64% | 57.5% | |||
| a | 36% | 42.5% | |||
| rs731236 TaqI | TT | 41 (41%) | 54 (54%) | 0.029* | 1 (Reference)OR = 1.98; p = 0.037 (95% CI: 1.05–8.47)OR = 4.63; p = 0.031 (95% CI: 1.09–19.7) |
| Tt | 45 (45%) | 27 (27%) | |||
| tt | 14 (14%) | 19 (19%) | |||
| T | 63.5% | 67.5% | |||
| t | 36.5% | 32.5% |
SNPs: single nucleotide polymorphisms; OR: odds ratios; CI: confidence intervals; * statistically significant. Two OR are reported for each genotype. The first OR corresponds to the comparison between BB and Bb (AA and Aa) (TT and Tt) genotypes, and the second OR compares BB and bb (AA and aa) (TT and tt) genotypes. Each OR is accompanied by its p-value and 95% CI