Exploration of Medicine

From: Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

Table 4

Top associations for time to OD in AAs

Chr	BP	rsID	A1	A2	GENE	Yale-Penn		COGA	Yale-Penn + COGA
Chr	BP	rsID	A1	A2	GENE	MAF	P	P	HR	P	Direction
2	8653036	rs113142991	A	C	LINC00299-LINC0184	0.07	1.81E-07	8.30E-01	1.57	6.48E-07	+++-
4	59826282	rs4860439	T	C	RP11-506N2.1	0.31	1.02E-07	6.50E-01	0.80	1.06E-07	----
4	95747400	rs11728570	T	C	BMPR1B	0.37	1.08E-05	4.90E-02	0.82	1.07E-06	----
9	118707243	rs115391335	T	C	LINC00474-LOC105376236	0.03	5.55E-07	1.80E-01	1.72	1.11E-07	+++-
10	49574826	rs1881736	A	T	MAPK8	0.04	1.47E-05	7.60E-03	0.63	3.73E-07	--+-
12	14086651	rs114341823	T	C	GRIN2B	0.03	8.75E-07	9.20E-02	1.70	1.77E-07	++++
12	53305274	rs114198947	A	G	KRT8	0.03	2.68E-06	8.80E-01	1.67	7.35E-07	++++

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The order of the symbols corresponds to Yale-Penn 1, Yale Penn 2, Yale-Penn 3, COGA. A1: effect allele; A2: non-effect allele; MAF: minor allele frequency in the AA subset of the Yale-Penn cohort; P: P-value; Direction: effect direction of A1